MacKenzie M R, Lewis J P
Cancer Genet Cytogenet. 1985 Aug;17(4):301-5. doi: 10.1016/0165-4608(85)90113-x.
A patient with IgG kappa multiple myeloma was studied cytogenetically prior to therapy and was found to have a clone of 55,XX cells. After treatment leading to a clinical response, the patient relapsed with a clone of 57,XX cells, which were derivatives of the original neoplastic cell line. This is the first case of demonstrated clonal evolution of myeloma in a patient studied prior to chemotherapy.
一名患有IgG κ型多发性骨髓瘤的患者在治疗前接受了细胞遗传学研究，发现有一个55,XX细胞克隆。经过治疗获得临床缓解后，患者复发，出现了一个57,XX细胞克隆，这些细胞是原始肿瘤细胞系的衍生物。这是首例在化疗前进行研究的患者中证实的骨髓瘤克隆进化病例。
