Jones D J, Moore M, Schofield P F
Department of Surgery, Christie Hospital and Holt Radium Institute, Manchester, UK.
Br J Surg. 1988 Jan;75(1):28-33. doi: 10.1002/bjs.1800750111.
A prospective study of prognostic factors has been carried out in a group of 123 consecutive patients with colorectal cancer. The fate of all patients is known at 3 years after operation. Clinical and pathological data were recorded at the time of presentation and operation, and the patients have been subject to regular postoperative review. DNA ploidy status was determined by flow cytometry. In all, 39 (33 per cent) patients had DNA diploid tumours and 80 (67 per cent) patients had DNA aneuploid tumours. In four cases, tumour material was not obtained. The patients with DNA aneuploid tumours had a worse prognosis than those with DNA diploid tumours, but this was only seen in those patients classified as Dukes' B. In a Cox's regression analysis, the surgeon's assessment of operability was the strongest predictor of survival, followed by the pathological classification and the patient's age. After these factors had been considered, the DNA ploidy status conferred no independent survival value.
对一组连续的123例结直肠癌患者进行了预后因素的前瞻性研究。所有患者术后3年的转归情况均已知晓。在就诊和手术时记录了临床和病理数据，并且患者接受了定期的术后复查。通过流式细胞术确定DNA倍体状态。总共有39例（33%）患者患有DNA二倍体肿瘤，80例（67%）患者患有DNA非整倍体肿瘤。有4例未获取到肿瘤组织。DNA非整倍体肿瘤患者的预后比DNA二倍体肿瘤患者差，但这仅在那些被归类为Dukes' B期的患者中可见。在Cox回归分析中，外科医生对可切除性的评估是生存的最强预测因素，其次是病理分类和患者年龄。在考虑了这些因素之后，DNA倍体状态没有独立的生存价值。
