Rognum T O, Thorud E, Lund E
Institute of Forensic Medicine, National Hospital, Oslo, Norway.
Br J Cancer. 1987 Nov;56(5):633-6. doi: 10.1038/bjc.1987.257.
One hundred patients operated for large bowel carcinoma were divided into a distinct aneuploid group of 63, and a near diploid one of 37. Flow cytometry was used for determination of the DNA ploidy pattern. All tumours in the aneuploid group contained one or more aneuploid cell populations. All patients were followed clinically from 3.5 to 7.8 years. The corrected 5 year survival was 64% and 49% for patients with near diploid and aneuploid tumours, respectively (not significant). Significant differences in corrected survival time were not observed for Dukes' stages A, B, and C patients pooled, nor for Dukes' stage D patients. However, for Dukes' stage C patients alone, there was a tendency (P = 0.10) for patients with near diploid tumours to show a better survival. A highly significant predominance of aneuploid tumours was seen in males, in contrast to an equal distribution of aneuploid and near diploid tumours in females. A slight predominance of aneuploid tumours in the left colon and rectum was seen. Both these findings indicate the influence of environmental factors (hormonal, anatomical, phenotypical) on the development of tumours with a particular DNA ploidy pattern.
100例接受大肠癌细胞手术的患者被分为明显的非整倍体组（63例）和近二倍体组（37例）。采用流式细胞术测定DNA倍体模式。非整倍体组中的所有肿瘤均包含一个或多个非整倍体细胞群。所有患者均接受了3.5至7.8年的临床随访。近二倍体肿瘤患者和非整倍体肿瘤患者的校正5年生存率分别为64%和49%（无显著性差异）。对于合并的Dukes分期A、B和C期患者以及Dukes分期D期患者，校正生存时间均未观察到显著差异。然而，仅对于Dukes分期C期患者，近二倍体肿瘤患者有生存较好的趋势（P = 0.10）。与女性非整倍体肿瘤和近二倍体肿瘤分布相等相比，男性非整倍体肿瘤明显占优势。在左半结肠和直肠中，非整倍体肿瘤略有优势。这两个发现均表明环境因素（激素、解剖学、表型）对具有特定DNA倍体模式的肿瘤发生发展的影响。
