视神经和视交叉低度胶质瘤的管理

Management of low-grade gliomas of the optic nerve and chiasm.

作者信息

Flickinger J C, Torres C, Deutsch M

机构信息

Joint Radiation Oncology Center, University of Pittsburgh, PA 15213.

出版信息

Cancer. 1988 Feb 15;61(4):635-42. doi: 10.1002/1097-0142(19880215)61:4<635::aid-cncr2820610403>3.0.co;2-2.

DOI:10.1002/1097-0142(19880215)61:4<635::aid-cncr2820610403>3.0.co;2-2

PMID:3338030

Abstract

Thirty-six patients were evaluated between 1965 and 1983 for glioma of the optic nerves and/or chiasm. Median follow-up was 10.2 years. Pathologic verification was obtained in 32 patients. Tumor initially confined to the optic nerve recurred in one of five patients after complete resection. The actuarial survival for 25 patients irradiated for biopsy-proven glioma of the optic chiasm was 96%, 90%, and 90% at 5, 10, and 15 years, respectively, and the progression-free survival was 87% at 5, 10, and 15 years. Vision stabilized or improved in 86% of patients after radiotherapy. Patients irradiated to a dose greater than a NSD of 1385 ret had a significantly improved progression-free survival (P = 0.015). One serious complication occurred after a dose of 1533 ret. The recommended radiation dose for optic glioma is 45 to 50 Gy with 1.8 Gy fractions.

摘要

1965年至1983年间，对36例视神经和/或视交叉胶质瘤患者进行了评估。中位随访时间为10.2年。32例患者获得了病理证实。最初局限于视神经的肿瘤在5例患者中的1例在完全切除后复发。25例经活检证实为视交叉胶质瘤并接受放疗的患者，其5年、10年和15年的精算生存率分别为96%、90%和90%，无进展生存率在5年、10年和15年分别为87%。放疗后86%的患者视力稳定或改善。接受剂量大于1385ret NSD照射的患者无进展生存率显著提高（P = 0.015）。在剂量为1533ret后发生了1例严重并发症。视神经胶质瘤的推荐放疗剂量为45至50 Gy，每次分割剂量为1.8 Gy。