Miller R R, Nelems B, Evans K G, Müller N L, Ostrow D N
Department of Pathology, Vancouver General Hospital, British Columbia, Canada.
Cancer. 1988 Mar 1;61(5):1009-14. doi: 10.1002/1097-0142(19880301)61:5<1009::aid-cncr2820610525>3.0.co;2-l.
In 62 consecutive resections for adenocarcinoma of the lung, 50 cases (81%) had single adenocarcinomas and 12 (19%) had multiple adenocarcinomas. In seven of these 12 patients, two adenocarcinomas were found. In the other five patients, the specimen contained a dominant adenocarcinoma and several 0.1- to 1-cm nodules of similar histologic appearance. In four of the 50 single tumor patients and one of seven double tumor patients, 1- to 2-mm nodules were found along with adenocarcinomas that we interpreted as being bronchioloalveolar tumors of uncertain malignant potential. An analogy is drawn between these four types of findings and single tumors of the colon, double tumors of the colon, polyposis syndromes, and tubular adenomas of the colon, respectively.
在连续62例肺癌腺癌切除术病例中，50例（81%）为单发腺癌，12例（19%）为多发腺癌。在这12例患者中，7例发现有两个腺癌。在另外5例患者中，标本包含一个主要腺癌和几个组织学表现相似、直径0.1至1厘米的结节。在50例单发肿瘤患者中的4例以及7例双发肿瘤患者中的1例中，除腺癌外还发现了1至2毫米的结节，我们将其解释为恶性潜能不确定的细支气管肺泡肿瘤。分别将这四种类型的发现与结肠单发肿瘤、结肠双发肿瘤、息肉病综合征以及结肠管状腺瘤进行了类比。
