Wang-Wuu S, Soukup S, Ballard E, Gotwals B, Lampkin B
Department of Human Genetics, Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Cancer Res. 1988 Feb 15;48(4):983-7.
Chromosomal analysis of 16 rhabdomyosarcomas was done from four primary tumors and from 12 tumors after nude mouse passage. Seven tumors were alveolar; four of these had t(2;13)(q37;q14) and in two tumors it was the only structural abnormality. The other three alveolar tumors were near tetraploid with marker chromosomes and double minutes. In the nine embryonal tumors studied, one had a normal karyotype, and eight were abnormal. Although the eight tumors had no common structural abnormality, trisomy 2 was present in all.
对16例横纹肌肉瘤进行了染色体分析，其中4例取自原发性肿瘤，12例取自裸鼠传代后的肿瘤。7例为肺泡型；其中4例有t(2;13)(q37;q14)，在2例肿瘤中这是唯一的结构异常。其他3例肺泡型肿瘤接近四倍体，有标记染色体和双微体。在研究的9例胚胎型肿瘤中，1例核型正常，8例异常。虽然这8例肿瘤没有共同的结构异常，但均存在2号染色体三体。
