冻融胚胎移植前注射人绒毛膜促性腺激素对子宫内膜异位症相关性不孕症妊娠结局的影响
Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility.
作者信息
Du Yanbo, Yan Lei, Sun Mei, Sheng Yan, Li Xiufang, Feng Zhenhua, Tang Rong
机构信息
Reproductive Hospital Affiliated to Shandong University, Jinan, China.
School of Medicine, Shandong University, Jinan, China.
出版信息
Front Med (Lausanne). 2020 Dec 14;7:592921. doi: 10.3389/fmed.2020.592921. eCollection 2020.
The aim of this study was to investigate the effect of human chorionic gonadotropin (hCG) in hormone replacement (HT) regime for frozen thawed embryo transfer in women with endometriosis (EM). We performed a retrospective, database-search, cohort study and included data on EM patients who underwent frozen embryo transfer (FET) between January 1, 2009 and August 31, 2018. According to the protocols for FET cycle, the patients were divided into two groups: control group ( = 296) and hCG group ( = 355). Clinical pregnancy rate, live birth rate, early abortion rate, late abortion rate, and ectopic pregnancy rate were compared between the two groups. There was a significant increase in clinical pregnancy rate in the hCG group (57.7 vs. 49%, = 0.027) compared with the control group. The live birth rate in the hCG group (45.6 vs. 38.5%, = 0.080) was also elevated, but this difference was not statistically significant. hCG administration in HT regime for FET increases the pregnancy rate in women with EM.
本研究旨在探讨人绒毛膜促性腺激素（hCG）在激素替代疗法（HT）方案中对子宫内膜异位症（EM）女性冻融胚胎移植的影响。我们进行了一项回顾性数据库检索队列研究，纳入了2009年1月1日至2018年8月31日期间接受冻融胚胎移植（FET）的EM患者数据。根据FET周期方案，将患者分为两组：对照组（n = 296）和hCG组（n = 355）。比较两组的临床妊娠率、活产率、早期流产率、晚期流产率和异位妊娠率。与对照组相比，hCG组的临床妊娠率显著提高（57.7%对49%，P = 0.027）。hCG组的活产率（45.6%对38.5%，P = 0.080）也有所提高，但这种差异无统计学意义。在FET的HT方案中使用hCG可提高EM女性的妊娠率。
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