人绒毛膜促性腺激素在着床中的作用：分子及临床证据的小型综述
The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence.
作者信息
Makrigiannakis Antonis, Vrekoussis Thomas, Zoumakis Emmanouel, Kalantaridou Sophia N, Jeschke Udo
机构信息
Department of Obstetrics and Gynecology, Medical School, University of Crete, Heraklion 71003, Greece.
Department of Obstetrics and Gynecology, Medical School, University of Ioannina, Ioannina 45110, Greece.
出版信息
Int J Mol Sci. 2017 Jun 19;18(6):1305. doi: 10.3390/ijms18061305.
Abstract
Embryo implantation is a complex process involving continuous molecular cross-talk between the embryo and the decidua. One of the key molecules during this process is human chorionic gonadotropin (HCG). HCG effectively modulates several metabolic pathways within the decidua contributing to endometrial receptivity. Herein, a brief overview of the molecular mechanisms regulated by HCG is presented. Furthermore, we summarize the existing evidence regarding the clinical impact on reproductive outcomes after endometrial priming with HCG prior to embryo transfer. Although promising, further evidence is needed to clarify the protocol that would lead to beneficial outcomes.
摘要
胚胎着床是一个复杂的过程，涉及胚胎与蜕膜之间持续的分子相互作用。在此过程中的关键分子之一是人绒毛膜促性腺激素（HCG）。HCG可有效调节蜕膜内的多种代谢途径，有助于子宫内膜接受性。本文简要概述了由HCG调节的分子机制。此外，我们总结了现有证据，这些证据涉及胚胎移植前用HCG进行子宫内膜预处理对生殖结局的临床影响。尽管前景乐观，但仍需要进一步的证据来阐明能带来有益结果的方案。
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