Karabulut Seda, Korkmaz Oya, Yılmaz Elif, Keskin Ilknur
Department of Histology and Embryology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Medistate Hospital, IVF Center, Istanbul, Turkey.
Andrologia. 2021 Mar;53(2):e13956. doi: 10.1111/and.13956. Epub 2020 Dec 30.
Oxidative stress (OS) has been shown to have a key role in male infertility. Recently, a new measurement method has been developed to measure the overall oxidation-reduction potential (ORP) in a semen sample known as the MiOXSYS system. The aim of this study was to investigate the correlation of sperm parameters with oxidative stress levels determined by ORP and to evaluate whether the current limit is able to distinguish abnormal sperm parameters from normal ones in Turkish population. Semen samples of 121 patients who applied for infertility investigation were divided into two groups as (OS +; n:39) and (OS -; n:82). Semen parameters were compared between groups. Sperm concentration, total motility and progressive motility were found to be significantly lower in OS (+) patients compared to those OS (-), while immotile sperm count was significantly higher in OS (+) patients. Oxidative stress determined by MiOXSYS system was found to be related to reduced sperm parameters in Turkish population, which may be used as an indicator of poor sperm parameters and a support to routine semen analysis. In addition, recommended reference value was found to be reliable in distinguishing normal from impaired semen parameters.
氧化应激（OS）已被证明在男性不育中起关键作用。最近，一种新的测量方法已被开发出来，用于测量精液样本中的总体氧化还原电位（ORP），即MiOXSYS系统。本研究的目的是探讨精子参数与通过ORP测定的氧化应激水平之间的相关性，并评估当前的限值是否能够区分土耳其人群中异常精子参数和正常精子参数。将121例申请不育症检查的患者的精液样本分为两组，即（OS+；n：39）和（OS-；n：82）。比较两组之间的精液参数。发现OS（+）患者的精子浓度、总活力和前向运动能力明显低于OS（-）患者，而OS（+）患者的不动精子计数明显更高。发现MiOXSYS系统测定的氧化应激与土耳其人群中精子参数降低有关，这可作为精子参数不良的指标，并辅助常规精液分析。此外，发现推荐的参考值在区分正常和受损精液参数方面是可靠的。
