Tan Yangyang, Yuan Yacheng, Yang Xukai, Wang Yong, Liu Linhai
Department of Urology, The Second People's Hospital of Neijiang, Neijiang, China.
The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou, China.
Transl Androl Urol. 2024 Jul 31;13(7):1228-1238. doi: 10.21037/tau-24-32. Epub 2024 Jul 16.
In the last few years, studies have initially confirmed the diagnostic significance of oxidation-reduction potential (ORP) in male infertility patients. In this article, we used meta-analysis to clarify the role of ORP in the diagnosis of male infertility.
PubMed, Embase, Web of Science, and Cochrane Library were searched by computer for relevant published literature. Quality assessment of the included literature was performed by Quality Assessment of Diagnostic Accuracy Studies (QUADAS) scale. Heterogeneity analysis of included studies was conducted using Metadisc 1.4 and Stata 12.0, and effective models for quantitative synthesis were selected based on heterogeneity results; the sensitivity and specificity of the synthesis were obtained using the software, and in order to reduce the effects of heterogeneity and thresholds, the information of sensitivity and specificity was integrated. We used the subject receiver operating characteristic (SROC) curve, area under the curve (AUC) and Q* index for comprehensive evaluation.
Seven papers were eventually included in the study, and the results showed that ORP had a sensitivity of 0.81 [95% confidence interval (CI): 0.80-0.82] and specificity of 0.66 (95% CI: 0.63-0.69), an AUC of 0.8 and a Q* index of 0.74 for the diagnosis of male infertility.
ORP has high sensitivity and specificity for diagnosing male infertility.
在过去几年中，研究初步证实了氧化还原电位（ORP）在男性不育患者中的诊断意义。在本文中，我们采用荟萃分析来阐明ORP在男性不育诊断中的作用。
通过计算机检索PubMed、Embase、Web of Science和Cochrane图书馆，查找相关的已发表文献。采用诊断准确性研究质量评估（QUADAS）量表对纳入文献进行质量评估。使用Metadisc 1.4和Stata 12.0对纳入研究进行异质性分析，并根据异质性结果选择有效的定量合成模型；使用该软件获得合成的敏感性和特异性，为减少异质性和阈值的影响，整合敏感性和特异性信息。我们使用受试者工作特征（SROC）曲线、曲线下面积（AUC）和Q*指数进行综合评估。
最终纳入7篇论文，结果显示ORP诊断男性不育的敏感性为0.81[95%置信区间（CI）：0.80 - 0.82]，特异性为0.66（95%CI：0.63 - 0.69），AUC为0.8，Q*指数为0.74。
ORP对男性不育的诊断具有较高的敏感性和特异性。
