Demirtaş Atılım Armağan, Karahan Mine, Erdem Seyfettin, Han Çağla Çilem, Keklikçi Uğur
Department of Ophthalmology, Health Sciences University, Tepecik Training and Research Hospital, Izmir, Turkey.
Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
Photodiagnosis Photodyn Ther. 2021 Mar;33:102160. doi: 10.1016/j.pdpdt.2020.102160. Epub 2020 Dec 28.
To investigate the effects of Ramadan fasting on diurnal superficial-deep parafoveal vessel density (pfVD) and nerve head (NH)-radial peripapillary capillary (RPC) peripapillary vessel density (ppVD) using optical coherence tomography angiography (OCTA), as well as other related oculodynamic and haemodynamic parameters, and to compare these findings with those in the nonfasting period in healthy individuals.
A total of 105 healthy individuals, 42 women and 63 men, were included in this prospective study. OCTA was used to examine the superficial-deep pfVD and NH-RPC ppVD. In the third week of Ramadan, OCTA readings were obtained twice daily at 08:00 and 16:00 hour (h) under fasting conditions and compared with nonfasting values 2 weeks after Ramadan. Both intraocular pressure (IOP) and blood pressure values were assessed accordingly.
The mean age (23-51) of individuals was 34.37 ± 7.04 years. In comparison with the 08:00 -h values, the 16:00 -h IOPs, superficial-deep pfVDs and RPC ppVDs were substantially reduced both during the fasting and nonfasting periods (P = 0.001, P = 0.009, P = 0.006, P = 0.006, P = 0.004, P = 0.004, P = 0.41, P = 0.032 and P = 0.021). No differences were found in the diurnal change of superficial-deep pfVDs, NH-RPC ppVDs, IOPs and mean ocular perfusion pressures (MOPPs) between the fasting and nonfasting periods, whereas the same was not true for mean arterial blood pressures (MABPs) (P = 0.049).
The parafoveal and peripapillary VDs (except for NHpp-VD) and IOPs were found to have decreased significantly throughout the day both in fasting and nonfasting periods. Our study confirms the diurnal changes in the IOPs, MOPPs, superficial-deep pfVDs and NH-RPC ppVDs under dehydration and normal terms.
利用光学相干断层扫描血管造影（OCTA）研究斋月禁食对昼夜黄斑旁中心凹浅表 - 深层血管密度（pfVD）和视乳头 - 视乳头周围放射状毛细血管（RPC）的视乳头周围血管密度（ppVD）的影响，以及其他相关眼动力学和血流动力学参数，并将这些结果与健康个体非禁食期的结果进行比较。
本前瞻性研究共纳入105名健康个体，其中42名女性和63名男性。使用OCTA检查浅表 - 深层pfVD和视乳头 - RPC的ppVD。在斋月的第三周，在禁食条件下，每天08:00和16:00两次获取OCTA读数，并与斋月后2周的非禁食值进行比较。相应地评估眼压（IOP）和血压值。
个体的平均年龄（23 - 51岁）为34.37±7.04岁。与08:00时的值相比，在禁食期和非禁食期，16:00时的IOP、浅表 - 深层pfVD和RPC ppVD均显著降低（P = 0.001、P = 0.009、P = 0.006、P = 0.006、P = 0.004、P = 0.004、P = 0.41、P = 0.032和P = 0.021）。在禁食期和非禁食期之间，浅表 - 深层pfVD、视乳头 - RPC ppVD、IOP和平均眼灌注压（MOPP）的昼夜变化未发现差异，而平均动脉血压（MABP）则不然（P = 0.049）。
发现无论是在禁食期还是非禁食期，黄斑旁和视乳头周围的血管密度（视乳头周围血管密度除外）和IOP全天均显著降低。我们的研究证实了脱水和正常情况下IOP、MOPP、浅表 - 深层pfVD和视乳头 - RPC ppVD的昼夜变化。
