Gene Inhibits Pyroptosis and Intestinal Inflammation to Aggravate Systemic Infection in Mice.

serovar Typhimurium (). Typhimurium is a primary foodborne pathogen infecting both humans and animals. plasmid virulence C () gene is closely related to . Typhimurium dissemination in mice, while the mechanisms remain to be fully elucidated. Pyroptosis, a gasdermin-mediated inflammatory cell death, plays a role in host defense against bacterial infection, whereas the effect of on pyroptosis and its function in inflammatory injury induced by . Typhimurium are rather limited. In our study, C57BL/6 mice and J774A.1 cells infected with . Typhimurium wild-type strain SL1344, deletion mutant, K136A site-directed mutant, and complemented strain were used to investigate potential pathogenesis of . We verity that SpvC attenuates intestinal inflammation, suppresses pyroptosis through phosphothreonine lyase activity, and reduces pyroptosis in the ceca. Moreover, the reduction of inflammation via results in systemic infection. These findings demonstrate that inhibits pyroptosis and intestinal inflammation to promote bacterial dissemination, which provide new strategies for controlling systemic infection caused by and novel insights for the treatment of other corresponding diseases.