III型分泌系统效应蛋白
Type III Secretion System Effectors.
作者信息
Worley Micah J
机构信息
Department of Biology, University of Louisville, Louisville, KY 40292, USA.
出版信息
Int J Mol Sci. 2025 Mar 14;26(6):2611. doi: 10.3390/ijms26062611.
Abstract
is estimated to infect between 200 million and over 1 billion people per year. The exact number is not known, as many cases go unreported. Integral to the pathogenesis of , as well as numerous other Gram-negative pathogens, is its type III effectors. possesses two distinct type III secretion systems, encoded by pathogenicity island-1 and pathogenicity island-2. Together, they secrete at least 49 type III effectors into host cells that are collectively responsible for many of the virulence attributes of this pathogen. These virulence factors facilitate the invasion of host cells, induce and attenuate inflammation, and change the migratory properties of infected phagocytes, among other things. The effects of all type III effectors on virulence are discussed.
摘要
据估计，每年有2亿至超过10亿人受到感染。确切数字尚不清楚，因为许多病例未被报告。其III型效应器是其发病机制以及许多其他革兰氏阴性病原体发病机制的重要组成部分。[病原体名称]拥有两个不同的III型分泌系统，由致病岛-1和致病岛-2编码。它们共同向宿主细胞分泌至少49种III型效应器，这些效应器共同导致了这种病原体的许多毒力特性。这些毒力因子有助于宿主细胞的入侵，诱导和减轻炎症，并改变受感染吞噬细胞的迁移特性等。文中讨论了所有III型效应器对[病原体名称]毒力的影响。
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