College of Animal Science and Technology/Laboratory of Functional Microbiology and Animal Health, Henan University of Science and Technology, Luoyang, Henan, China.
The Key Lab of Animal Disease and Public Health/Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, Henan, China.
Front Immunol. 2024 Oct 23;15:1464858. doi: 10.3389/fimmu.2024.1464858. eCollection 2024.
The genus contains the most common foodborne pathogens frequently isolated from food-producing animals and is responsible for zoonotic infections in humans and animals. infection in humans and animals can cause intestinal damage, resulting in intestinal inflammation and disruption of intestinal homeostasis more severe cases can lead to bacteremia. Pyroptosis, a proinflammatory form of programmed cell death, is involved in many disease processes. Inflammasomes, pyroptosis, along with their respective signaling cascades, are instrumental in the preservation of intestinal homeostasis. In recent years, with the in-depth study of pyroptosis, our comprehension of the virulence factors and effector proteins in has reached an extensive level, a deficit persists in our knowledge regarding the intrinsic pathogenic mechanisms about pyroptosis, necessitating a continued pursuit of understanding and investigation. In this review, we discuss the occurrence of pyroptosis induced by effectors to provide new ideas for elucidating the regulatory mechanisms through which virulence factors and effector proteins trigger pyroptosis could pave the way for novel concepts and strategies in the clinical prevention of infections and the treatment of associated diseases.
该属包含最常见的食源性病原体，经常从生产动物的食品中分离出来，是人类和动物中动物源性感染的罪魁祸首。人类和动物的感染可导致肠道损伤，引起肠道炎症和肠道内稳态紊乱，更严重的情况下可导致菌血症。细胞焦亡是一种促炎形式的程序性细胞死亡，参与许多疾病过程。炎性小体是细胞焦亡的关键，与其各自的信号级联一起，对维持肠道内稳态至关重要。近年来，随着对细胞焦亡的深入研究，我们对 中毒力因子和效应蛋白的认识已经达到了广泛的水平，但我们对细胞焦亡内在发病机制的了解仍然存在不足，需要继续探索和研究。在这篇综述中，我们讨论了效应蛋白诱导的细胞焦亡的发生，为阐明 毒力因子和效应蛋白触发细胞焦亡的调节机制提供了新的思路，为临床预防 感染和相关疾病的治疗提供了新的概念和策略。
