Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Centro de Desenvolvimento Científico e Tecnológico, Secretaria Estadual da Saúde do Rio Grande do Sul (CDCT/SES), Porto Alegre, RS, Brazil.
Infection. 2021 Jun;49(3):457-461. doi: 10.1007/s15010-020-01562-w. Epub 2021 Jan 1.
The establishment of candidate genetic determinants associated with tuberculosis (TB) is a challenge, considering the divergent frequencies among populations. The objective of this study was to evaluate the association between MIF - 794 CATT polymorphism and susceptibility to TB.
Case-control study. Patients > 18 years, with pulmonary TB were included. The control group consisted of blood donors and household contacts, not relatives, healthy and > 18 years. MIF - 794 CATT were genotyped using sequencing of PCR and capillary electrophoresis.
126 patients and 119 controls were included. The genotype 5/5 was more frequent among cases (15.1%) than in controls (5.9%) (p = 0.019). Cases had more frequently the allele 5 (29.4%) as compared with controls (19.3%) (p = 0.010). Prevalence of 7/X + 8/X genotypes was not different between cases and controls (p = 0.821). There was no difference between patients with alleles 7 and 8 and those with alleles 5 and 6 (p = 0.608).
The genotype 5/5 and the allele 5 of MIF - 794 CATT were more frequent among TB patients than in controls.
考虑到人群之间存在的频率差异，确定与结核病（TB）相关的候选遗传决定因素是一项挑战。本研究旨在评估 MIF-794 CATT 多态性与 TB 易感性之间的关联。
病例对照研究。纳入年龄>18 岁、患有肺结核的患者。对照组由献血者和家庭接触者组成，他们不是亲属，身体健康且年龄>18 岁。使用 PCR 测序和毛细管电泳法对 MIF-794 CATT 进行基因分型。
共纳入 126 例患者和 119 例对照。病例组中 5/5 基因型（15.1%）比对照组（5.9%）更为常见（p=0.019）。病例组中 5 等位基因（29.4%）的频率高于对照组（19.3%）（p=0.010）。病例组和对照组 7/X+8/X 基因型的患病率无差异（p=0.821）。携带等位基因 7 和 8 的患者与携带等位基因 5 和 6 的患者之间无差异（p=0.608）。
MIF-794 CATT 的 5/5 基因型和 5 等位基因在 TB 患者中比在对照组中更为常见。
