The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
Genomics. 2021 Mar;113(2):490-496. doi: 10.1016/j.ygeno.2020.12.034. Epub 2020 Dec 29.
Steroid-induced necrosis of femoral head (SINFH) is a femoral head necrotic disease caused by prolonged use of hormones. The detailed pathogenesis has not been fully demonstrated. In this study, we employed the bioinformatics approach to probe the roles of SINFH inhibitors. Core dysfunction modules related to SINFH was obtained. Meanwhile, GO and KEGG analysis of genes in dysfunction modules are carried out. Furthermore, the pivot prediction analysis of dysfunction modules related to ncRNA and transcription factor (TF) has been performed. The functions of the enriched modules were focused on multiple perspectives, including circulation, gland development, bone development and reconstruction, calcium production, and fatty acid metabolism regulation. The ncRNAs and TFs analysis showed that miR-322-5p, miR-124-3p, miR-125a-3p, and Ctnnb1 were important members of SINFH dysfunction. Drug targets suggested that Zinc and adenosine monophosphate may have an impact on SINFH dysfunction. SINFH was closely related to bone development and reconstruction.
激素性股骨头坏死（SINFH）是一种由于长期使用激素引起的股骨头坏死疾病。其详细的发病机制尚未完全阐明。在本研究中，我们采用生物信息学方法探讨 SINFH 抑制剂的作用。获得与 SINFH 相关的核心功能失调模块。同时，对功能失调模块中的基因进行 GO 和 KEGG 分析。进一步对与 ncRNA 和转录因子（TF）相关的功能失调模块进行关键预测分析。富集模块的功能从多个角度进行了关注，包括循环、腺体发育、骨发育和重建、钙产生以及脂肪酸代谢调节。ncRNA 和 TF 分析表明，miR-322-5p、miR-124-3p、miR-125a-3p 和 Ctnnb1 是 SINFH 功能失调的重要成员。药物靶点表明锌和单磷酸腺苷可能对 SINFH 功能失调有影响。SINFH 与骨发育和重建密切相关。
