Tanaka M, Sarr M G
Department of Surgery, Mayo Medical School, Rochester, Minnesota.
Gastroenterology. 1988 Mar;94(3):622-9. doi: 10.1016/0016-5085(88)90232-6.
This study was designed to determine the role of the duodenum in controlling the interdigestive migrating motor complex of the canine stomach and small intestine. The motility patterns of 4 dogs were studied before and after resection of the entire duodenum with reimplantation of bile and pancreatic ducts. Before duodenectomy, plasma concentrations of motilin and pancreatic polypeptide varied cyclically with the migrating motor complex. After duodenectomy, the migrating motor complex was abolished in the stomach in 3 of the 4 dogs during fasting. The other dog demonstrated what appeared to be an intermittent cyclic increase in gastric contractile activity, but with markedly abnormal characteristics and at irregular intervals. The jejunal migrating motor complex continued to cycle after duodenectomy in all 4 dogs, but the mean period was shorter than before duodenectomy (83 min vs. 147 min, p less than 0.01). Duodenectomy abolished the cyclic variations of plasma motilin and pancreatic polypeptide and lowered the concentration of both peptides during all phases. This study suggests that the duodenum plays an important role in the initiation of the gastric migrating motor complex and in the coordination of interdigestive gastrointestinal motor activity, possibly by the release of motilin.
本研究旨在确定十二指肠在控制犬胃和小肠消化间期移行性运动复合波中的作用。对4只犬在切除整个十二指肠并重新植入胆管和胰管前后的运动模式进行了研究。十二指肠切除术前，胃动素和胰多肽的血浆浓度随移行性运动复合波呈周期性变化。十二指肠切除术后，4只犬中有3只在禁食期间胃内的移行性运动复合波消失。另一只犬表现出胃收缩活动似乎有间歇性周期性增加，但特征明显异常且间隔不规律。十二指肠切除术后，所有4只犬空肠的移行性运动复合波仍继续循环，但平均周期比十二指肠切除术前短（83分钟对147分钟，p<0.01）。十二指肠切除术消除了血浆胃动素和胰多肽的周期性变化，并使两个阶段中两种肽的浓度均降低。本研究表明，十二指肠可能通过释放胃动素在胃移行性运动复合波的起始以及消化间期胃肠运动活动的协调中发挥重要作用。
