Tanaka M, Sarr M G
Department of Surgery, Mayo Medical School, Rochester, MN 55905.
Surgery. 1988 Aug;104(2):317-25.
Our aim was to determine the role of endogenous motilin in initiation of motor patterns of the upper gut. We studied the motor response to intravenous motilin and morphine in six dogs after total duodenectomy and in six normal dogs. Motilin (0.1 micrograms/kg) and morphine (200 micrograms/kg) induced large-amplitude gastric contractions after duodenectomy. The duration of gastric contractions after motilin (4.4 +/- 0.3 minutes; mean +/- SEM) was less than spontaneous or motilin-induced gastric phase III in controls (21 +/- 2 minutes and 11 +/- 2 minutes, respectively; p less than 0.01), while the response to morphine (7.4 +/- 3.7 minutes) was less than spontaneous (21 +/- 2 minutes; p less than 0.01) but similar to morphine-induced phase III in controls (7.7 +/- 0.9 minutes). After morphine, plasma motilin increased by 51 +/- 6 pg/ml, but the magnitude of increase was not correlated with the effectiveness of morphine in inducing gastric contractions. Both agents induced phase III-like activity in the jejunum. The durations of jejunal phase III activity after motilin (6.2 +/- 0.3 minutes) and morphine (6.4 +/- 0.3 minutes) were greater than spontaneous phase III after duodenectomy (4.8 +/- 0.4 minutes; p less than or equal to 0.05) and in controls (4.7 +/- 0.2 minutes; p less than 0.05). The latency of response to motilin in the stomach (0.2 +/- 0.1 minute) was less than in jejunum (8.9 +/- 0.6; p less than 0.05), but the latency after morphine was not different in stomach and jejunum (2.9 +/- 0.9 minutes and 2.8 +/- 0.8 minutes, respectively). These observations suggested that the duodenum, possibly by the release of endogenous motilin, may "recruit" and further augment the gastric response to initiation of the migrating motor complex. Also, the mechanism for initiation of the migrating motor complex in the stomach and in the jejunum may differ.
我们的目的是确定内源性胃动素在上消化道运动模式启动中的作用。我们研究了6只全十二指肠切除术后的犬和6只正常犬对静脉注射胃动素和吗啡的运动反应。胃动素（0.1微克/千克）和吗啡（200微克/千克）在十二指肠切除术后诱发大幅度胃收缩。胃动素注射后胃收缩的持续时间（4.4±0.3分钟；平均值±标准误）短于对照组自发或胃动素诱发的胃Ⅲ期（分别为21±2分钟和11±2分钟；p<0.01），而对吗啡的反应（7.4±3.7分钟）短于自发反应（21±2分钟；p<0.01），但与对照组吗啡诱发的Ⅲ期（7.7±0.9分钟）相似。注射吗啡后，血浆胃动素升高51±6皮克/毫升，但升高幅度与吗啡诱发胃收缩的有效性无关。两种药物均在空肠诱发Ⅲ期样活动。胃动素（6.2±0.3分钟）和吗啡（6.4±0.3分钟）注射后空肠Ⅲ期活动的持续时间长于十二指肠切除术后（4.8±0.4分钟；p≤0.05）和对照组（4.7±0.2分钟；p<0.05）的自发Ⅲ期。胃对胃动素反应的潜伏期（0.2±0.1分钟）短于空肠（8.9±0.6；p<0.05），但吗啡注射后胃和空肠的潜伏期无差异（分别为2.9±0.9分钟和2.8±0.8分钟）。这些观察结果表明，十二指肠可能通过释放内源性胃动素，“募集”并进一步增强胃对移行性运动复合波启动的反应。此外，胃和空肠中移行性运动复合波启动的机制可能不同。
