Graduate Program Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Oral Dis. 2022 Mar;28(2):390-397. doi: 10.1111/odi.13765. Epub 2021 Feb 2.
To evaluate the role of Helicobacter pylori and other risk factors in recurrent aphthous stomatitis (RAS).
Patients with functional dyspepsia responded to questionnaires regarding demographic and clinical data, anxiety and depression, and a specific RAS questionnaire. They underwent upper digestive endoscopy and H. pylori evaluation.
476 patients were included and of the 372 evaluated for H. pylori, 65.6% were H. pylori-positive. RAS was reported by 32.6% (155/476). In the bivariate analysis of the 372 patients evaluated for gastric H. pylori status, positive subjects had a lower RAS prevalence (29.9%; 73/244) than H. pylori-negative (41.4%; 53/128) (p = .026). Smoking (p = .005) and older age (p = .034) were also associated with a lower prevalence, while female gender (p = .032) and lower income (p = .046) presented higher RAS prevalence. In the multivariate analysis, H. pylori infection (p = .017), smoking (p = .001), and older age (p = .013) were protective factors, while lower income (p = .030) and anxiety (p = .042) were risk factors. In the multivariate analysis of all patients, female gender, lower income, and more schooling years were risk factors.
An unexpected lower prevalence of RAS was found in H. pylori-positive patients. Smoking, sex, age, income, education, and anxiety were associated with RAS.
评估幽门螺杆菌和其他危险因素在复发性阿弗他口炎（RAS）中的作用。
功能性消化不良患者对人口统计学和临床数据、焦虑和抑郁以及特定的 RAS 问卷进行了问卷调查。他们接受了上消化道内窥镜检查和幽门螺杆菌评估。
共纳入 476 例患者，其中 372 例接受了幽门螺杆菌评估，65.6%为幽门螺杆菌阳性。476 例患者中有 32.6%（155/476）报告有 RAS。在对 372 例接受胃幽门螺杆菌状态评估的患者进行的单变量分析中，阳性患者的 RAS 患病率较低（29.9%；73/244），而非幽门螺杆菌阴性患者的 RAS 患病率较高（41.4%；53/128）（p=0.026）。吸烟（p=0.005）和年龄较大（p=0.034）也与较低的患病率相关，而女性（p=0.032）和较低的收入（p=0.046）则与较高的 RAS 患病率相关。在多变量分析中，幽门螺杆菌感染（p=0.017）、吸烟（p=0.001）和年龄较大（p=0.013）是保护因素，而较低的收入（p=0.030）和焦虑（p=0.042）是危险因素。在所有患者的多变量分析中，女性、较低的收入和更多的受教育年限是危险因素。
在幽门螺杆菌阳性患者中发现 RAS 的患病率出乎意料地较低。吸烟、性别、年龄、收入、教育和焦虑与 RAS 相关。
