Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Curr Pharm Des. 2021;27(9):1144-1152. doi: 10.2174/1381612826666210101154118.
The current 2019-nCoV outbreak is becoming extremely harmful and has affected the whole world. Its control is challenging because there is no effective vaccine or drug available for coronavirus disease. The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), previously named as 2019 novel coronavirus (2019-nCoV), primarily targets the human respiratory system to lung lesions and lethal pneumonia. Natural products have always shown a crucial role in the process of drug development against various diseases. They may serve as leads for further drug development to combat emergent mutants of the coronavirus. In this review, the current status of natural compounds and their derivatives acting against different species of CoV are discussed.
目前的 2019-nCoV 疫情正在变得极其有害,并已影响到全世界。由于目前没有针对冠状病毒疾病的有效疫苗或药物,因此控制疫情具有挑战性。严重急性呼吸系统综合征冠状病毒-2(SARS-CoV-2),以前称为 2019 年新型冠状病毒(2019-nCoV),主要针对人类呼吸系统导致肺部病变和致命性肺炎。天然产物在针对各种疾病的药物开发过程中一直发挥着关键作用。它们可能成为针对冠状病毒的新兴突变体进一步药物开发的先导化合物。在这篇综述中,讨论了针对不同种类的 CoV 的天然化合物及其衍生物的现状。