Mrgprs 的信号通路和多态性。
The signaling pathway and polymorphisms of Mrgprs.
机构信息
School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, United States.
School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, United States.
出版信息
Neurosci Lett. 2021 Jan 23;744:135562. doi: 10.1016/j.neulet.2020.135562. Epub 2020 Dec 31.
Abstract
Mas-related G protein-coupled receptors (Mrgprs) are a family of receptors implicated in a diverse array of human diseases. Since their discovery in 2001, great progress has been made in determining their relation to human disease. Vital for Mrgprs therapeutic efforts across all disease disciplines is a thorough understanding of Mrgprs signal transduction pathways and polymorphisms, as these offer insights into new drug candidates, existing discrepancies in drug response, and differences in disease susceptibility. In this review, we discuss the current state of knowledge regarding Mrgprs signaling pathways and polymorphisms.
摘要
Mas 相关 G 蛋白偶联受体（Mrgprs）是一类受体家族，与多种人类疾病有关。自 2001 年发现以来，人们在确定它们与人类疾病的关系方面取得了很大进展。对于所有疾病领域的 Mrgprs 治疗工作来说，理解 Mrgprs 的信号转导途径和多态性至关重要，因为这可以为新的药物候选物、药物反应的现有差异以及疾病易感性的差异提供线索。在这篇综述中，我们讨论了目前关于 Mrgprs 信号转导途径和多态性的知识状况。
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