Golasiński Karol Marek, Detsch Rainer, Szklarska Magdalena, Łosiewicz Bożena, Zubko Maciej, Mackiewicz Sławomir, Pieczyska Elżbieta Alicja, Boccaccini Aldo Roberto
Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106, Warsaw, Poland.
Institute of Biomaterials, University of Erlangen-Nuremberg, 91058, Erlangen, Germany.
J Mech Behav Biomed Mater. 2021 Mar;115:104289. doi: 10.1016/j.jmbbm.2020.104289. Epub 2020 Dec 24.
In recent decades, several novel Ti alloys have been developed in order to produce improved alternatives to the conventional alloys used in the biomedical industry such as commercially pure titanium or dual phase (alpha and beta) Ti alloys. Gum Metal with the non-toxic composition Ti-36Nb-2Ta-3Zr-0.3O (wt. %) is a relatively new alloy which belongs to the group of metastable beta Ti alloys. In this work, Gum Metal has been assessed in terms of its mechanical properties, corrosion resistance and cell culture response. The performance of Gum Metal was contrasted with that of Ti-6Al-4V ELI (extra-low interstitial) which is commonly used as a material for implants. The advantageous mechanical characteristics of Gum Metal, e.g. a relatively low Young's modulus (below 70 GPa), high strength (over 1000 MPa) and a large range of reversible deformation, that are important in the context of potential implant applications, were confirmed. Moreover, the results of short- and long-term electrochemical characterization of Gum Metal showed high corrosion resistance in Ringer's solution with varied pH. The corrosion resistance of Gum Metal was best in a weak acid environment. Potentiodynamic polarization studies revealed that Gum Metal is significantly less susceptible to pitting corrosion compared to Ti-6Al-4V ELI. The oxide layer on the Gum Metal surface was stable up to 8.5 V. Prior to cell culture, the surface conditions of the samples, such as nanohardness, roughness and chemical composition, were analyzed. Evaluation of the in vitro biocompatibility of the alloys was performed by cell attachment and spreading analysis after incubation for 48 h. Increased in vitro MC3T3-E1 osteoblast viability and proliferation on the Gum Metal samples was observed. Gum Metal presented excellent properties making it a suitable candidate for biomedical applications.
近几十年来，为了研发出比生物医学行业中使用的传统合金（如工业纯钛或双相（α和β）钛合金）性能更优的替代品，人们开发了几种新型钛合金。无毒成分Ti-36Nb-2Ta-3Zr-0.3O（重量百分比）的牙龈金属是一种相对较新的合金，属于亚稳β钛合金组。在这项工作中，对牙龈金属的力学性能、耐腐蚀性和细胞培养反应进行了评估。将牙龈金属的性能与常用作植入材料的Ti-6Al-4V ELI（超低间隙）的性能进行了对比。牙龈金属具有有利的力学特性，例如相对较低的杨氏模量（低于70 GPa）、高强度（超过1000 MPa）和大范围的可逆变形，这些在潜在植入应用中很重要，这一点得到了证实。此外，牙龈金属的短期和长期电化学表征结果表明，其在不同pH值的林格氏溶液中具有高耐腐蚀性。牙龈金属在弱酸环境中的耐腐蚀性最佳。动电位极化研究表明，与Ti-6Al-4V ELI相比，牙龈金属更不易发生点蚀。牙龈金属表面的氧化层在高达8.5 V时是稳定的。在进行细胞培养之前，分析了样品的表面条件，如纳米硬度、粗糙度和化学成分。通过孵育48小时后的细胞附着和铺展分析，对合金的体外生物相容性进行了评估。观察到牙龈金属样品上体外MC3T3-E1成骨细胞的活力和增殖增加。牙龈金属具有优异的性能，使其成为生物医学应用的合适候选材料。
