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牙科种植体用β 型钛合金的最新进展及展望。

Recent Advances and Prospects in β-type Titanium Alloys for Dental Implants Applications.

机构信息

Department of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo 13414-903, Brazil.

Department of Materials Engineering (DEMa), Universidade Federal de São Carlos (UFSCar), São Carlos, São Paulo 13565-905, Brazil.

出版信息

ACS Biomater Sci Eng. 2024 Oct 14;10(10):6029-6060. doi: 10.1021/acsbiomaterials.4c00963. Epub 2024 Aug 30.

Abstract

Titanium and its alloys, especially Ti-6Al-4V, are widely studied in implantology for their favorable characteristics. However, challenges remain, such as the high modulus of elasticity and concerns about cytotoxicity. To resolve these issues, research focuses on β-type titanium alloys that incorporate elements such as Mo, Nb, Sn, and Ta to improve corrosion resistance and obtain a lower modulus of elasticity compatible with bone. This review comprehensively examines current β titanium alloys, evaluating their mechanical properties, in particular the modulus of elasticity, and corrosion resistance. To this end, a systematic literature search was carried out, where 81 articles were found to evaluate these outcomes. In addition, this review also covers the formation of the alloy, processing methods such as arc melting, and its physical, mechanical, electrochemical, tribological, and biological characteristics. Because β-Ti alloys have a modulus of elasticity closer to that of human bone compared to other metal alloys, they help reduce stress shielding. This is important because the alloy allows for a more even distribution of forces by having a modulus of elasticity more similar to that of bone. In addition, these alloys show good corrosion resistance due to the formation of a noble titanium oxide layer, facilitated by the incorporation of β stabilizers. These alloys also show significant improvements in mechanical strength and hardness. Finally, they also have lower cytotoxicity and bacterial adhesion, depending on the β stabilizer used. However, there are persistent challenges that require detailed research in critical areas, such as optimizing the composition of the alloy to achieve optimal properties in different clinical applications. In addition, it is crucial to study the long-term effects of implants on the human body and to advance the development of cutting-edge manufacturing techniques to guarantee the quality and biocompatibility of implants.

摘要

钛及其合金,特别是 Ti-6Al-4V,因其优良的特性在植入物领域得到了广泛的研究。然而,仍然存在一些挑战,如弹性模量高和细胞毒性问题。为了解决这些问题,研究集中在β型钛合金上,这些合金中加入了 Mo、Nb、Sn 和 Ta 等元素,以提高耐腐蚀性并获得与骨骼更兼容的较低弹性模量。

本综述全面考察了当前的β钛合金,评估了它们的机械性能,特别是弹性模量和耐腐蚀性。为此,进行了系统的文献检索,发现有 81 篇文章评估了这些结果。此外,本综述还涵盖了合金的形成、电弧熔炼等加工方法以及其物理、机械、电化学、摩擦学和生物学特性。

由于β-Ti 合金的弹性模量与人骨更接近,与其他金属合金相比,它有助于减少应力屏蔽。这一点很重要,因为合金的弹性模量更接近骨骼,有助于更均匀地分布力。此外,由于β稳定剂的加入,这些合金形成了一种贵金属氧化钛层,因此具有良好的耐腐蚀性。这些合金还在机械强度和硬度方面有显著提高。最后,它们的细胞毒性和细菌粘附性也较低,具体取决于所使用的β稳定剂。

然而,仍存在一些需要在关键领域进行详细研究的持续挑战,例如优化合金的成分,以在不同的临床应用中实现最佳性能。此外,研究植入物对人体的长期影响并推进先进制造技术的发展以保证植入物的质量和生物相容性至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b88/11480944/1a7de19330b2/ab4c00963_0001.jpg

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