Nowak D, Schmidt-Preuss U, Jörres R, Liebke F, Rüdiger H W
Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, FRG.
Int J Cancer. 1988 Feb 15;41(2):169-73. doi: 10.1002/ijc.2910410202.
Formation of DNA adducts and of water-soluble metabolites was studied in monocytes of 86 first-degree relatives of 15 families. Tests were performed with blood monocytes using (G-3H)-benzo[a]pyrene as a model pro-carcinogen. Variance analysis revealed significantly higher inter-familial than intra-familial variations. From these data we conclude that the formation of DNA adducts is genetically controlled. Therefore the enhanced formation of benzo[a]pyrene DNA adducts in lung cancer patients found in earlier studies may reflect a genetic predisposition for lung cancer in some patients.
在15个家庭的86名一级亲属的单核细胞中研究了DNA加合物和水溶性代谢物的形成。使用（G-3H）-苯并[a]芘作为模型致癌物对血液单核细胞进行检测。方差分析显示，家族间变异显著高于家族内变异。从这些数据我们得出结论，DNA加合物的形成受遗传控制。因此，早期研究中在肺癌患者中发现的苯并[a]芘DNA加合物形成增加可能反映了一些患者患肺癌的遗传易感性。
