有肺癌家族史的肺癌患者血液单核细胞中苯并[a]芘-DNA加合物的形成。
Formation of benzo[a]pyrene-DNA adducts in blood monocytes from lung cancer patients with a familial history of lung cancer.
作者信息
Nowak D, Meyer A, Schmidt-Preuss U, Gatzemeier U, Magnussen H, Rüdiger H W
机构信息
Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie.
出版信息
J Cancer Res Clin Oncol. 1992;118(1):67-71. doi: 10.1007/BF01192314.
Abstract
The in vitro formation of benzo[a]pyrene-DNA adducts was determined in peripheral blood monocytes of 22 lung cancer patients with at least one first-degree relative with lung cancer and compared to results obtained in 30 healthy controls. In patients, the mean (SEM) adduct formation was 2.8 (0.3) fmol/micrograms DNA as compared to 2.1 (0.1) fmol/micrograms in controls (p less than 0.05), and it was independent of age and smoking habits. These findings support the hypothesis that carcinogen-DNA adduct formation may be one factor of a constitutionally enhanced lung cancer risk.
摘要
在22名至少有一名肺癌一级亲属的肺癌患者的外周血单核细胞中测定了苯并[a]芘-DNA加合物的体外形成情况，并与30名健康对照者的结果进行了比较。在患者中，加合物形成的平均值（标准误）为2.8（0.3）fmol/微克DNA，而对照组为2.1（0.1）fmol/微克（p<0.05），且其与年龄和吸烟习惯无关。这些发现支持了致癌物-DNA加合物形成可能是体质性肺癌风险增加的一个因素这一假说。
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Enhanced benzo(a)pyrene metabolism and formation of DNA adducts in monocytes of patients with lung cancer.肺癌患者单核细胞中苯并(a)芘代谢增强及DNA加合物的形成
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Enhanced formation of benzo(a)pyrene:DNA adducts in monocytes of patients with a presumed predisposition to lung cancer.肺癌疑似易感患者单核细胞中苯并(a)芘:DNA加合物形成增加。
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