Department of Radionuclide Diagnostics, Medical Radiological Research Centre, Korolyev St. 4, Obninsk, 249036, Kaluga Region, Russia.
Strategic Health Innovation Partnerships, Medical Research Council, Tygerberg, 7505, Western Cape, South Africa.
Radiat Environ Biophys. 2021 Mar;60(1):165-178. doi: 10.1007/s00411-020-00884-5. Epub 2021 Jan 2.
Frequently knowledge of elemental content of human organs and tissues is required for a variety of applications. These can include brachytherapy and radiotherapy planning, radiation dosimetry and radiation protection. Revised reference values of chemical element mass fractions in normal and cancerous prostate tissues of the Reference (European Caucasian) Man are suggested as a result of this work. Autopsies of 37 apparently healthy males (mean age 55 ± 11 years, range 41-87 years) provided the prostatic tissues studied. The investigated individuals lived in a non-industrial, Central European region of Russia and had suffered sudden death. Also, tissues were studied from 62 subjects with prostate cancer (mean age 65 ± 10 years, range 40-79 years). Sixty-seven elemental mass fractions were determined in each of these 99 prostates. Analytical methods employed were inductively coupled plasma atomic emission spectrometry, neutron activation analysis with high-resolution spectrometry of short-lived and long-lived radionuclides, energy dispersive X-ray fluorescence analysis, and inductively coupled plasma mass spectrometry. Whichever method was employed, the necessary quality control measures were utilized. Results presented here include a systematic analysis of both the prostatic data presented here for 67 elements and also others' published findings, to make a total of 71 elemental mass fraction values.
经常需要了解人体器官和组织的元素含量，用于各种应用，包括近距离治疗和放射治疗计划、辐射剂量学和辐射防护。本工作提出了参考（欧洲白种人）男性正常和癌变前列腺组织中化学元素质量分数的修订参考值。对 37 名明显健康的男性（平均年龄 55 ± 11 岁，范围 41-87 岁）进行尸检，提供了所研究的前列腺组织。这些研究对象生活在俄罗斯中部一个非工业地区，死因是突然死亡。此外，还对 62 名前列腺癌患者（平均年龄 65 ± 10 岁，范围 40-79 岁）的组织进行了研究。在这 99 个前列腺中，每个前列腺都测定了 67 种元素的质量分数。采用的分析方法是电感耦合等离子体原子发射光谱法、带有短寿命和长寿命放射性核素高分辨率光谱的中子活化分析、能量色散 X 射线荧光分析和电感耦合等离子体质谱法。无论采用哪种方法，都采用了必要的质量控制措施。本文提供了对 67 种元素的前列腺数据的系统分析，以及其他已发表研究结果的分析，总共得到了 71 种元素质量分数值。
