Department of Medicine, Geriatrics Division, University of Verona, Ospedale Maggiore, Piazzale Stefani 1, 37126, Verona, Italy.
Department of Medicine, University of Verona, Verona, Italy.
Aging Clin Exp Res. 2021 Sep;33(9):2593-2597. doi: 10.1007/s40520-020-01763-1. Epub 2021 Jan 2.
Previous studies showed a strong relationship between reduction of appendicular muscle mass and worsening disability; hence, accuracy in assessing muscle mass is considered a key feature for a sarcopenia screening tool.
The aim of the study was to evaluate if the 7 items of Mini Sarcopenia Risk Assessment (MSRA) questionnaire predict muscle mass loss in a population of community-dwelling elderly subjects over a 5.5-y follow-up.
The study included 159 subjects, 92 women and 67 men aged 71.5 ± 2.2 years and with mean body mass index of 26.7 ± 4.0 kg/m. Appendicular skeletal muscle mass (ASMM) as measured with Dual-Energy X-ray absorptiometry (DXA), was obtained at baseline and after 2 and 5.5 years of follow-up where the skeletal muscle index (SMI) was calculated.
A significant reduction of ASMM and SMI was observed at two and 5.5 years of follow-up, in both, men and women. Repeated-measures analysis of variance (ANOVA) found a significant time effect on ASMM for both subjects with MSRA > 30 and ≤ 30 (P < 0.01 and P < 0.001). The group × time interaction was significant (P < 0.001), after even considering separately subjects with normal muscle mass and low muscle mass at baseline (P < 0.05 and P = 0.005). Similar results were obtained for SMI. Considering only the subjects with normal SMI at baseline, subjects with MSRA questionnaire ≤ 30 showed 5.7 (95% CI 1.73-19.03) higher risk of exceeding the low muscle mass threshold.
In a population of community-dwelling elderly men and women, MSRA score of 30 is predictive of a steeper decline in ASMM and SMI and of a higher risk of exceeding the low muscle mass EWGSOP threshold.
先前的研究表明，四肢肌肉质量的减少与残疾程度的恶化之间存在很强的关系；因此，准确评估肌肉质量被认为是肌少症筛查工具的关键特征。
本研究旨在评估迷你肌少症风险评估（MSRA）问卷的 7 项条目是否可预测社区居住的老年人群在 5.5 年随访中肌肉质量的丧失。
该研究纳入了 159 名受试者，其中 92 名女性，67 名男性，年龄为 71.5±2.2 岁，平均体重指数为 26.7±4.0kg/m2。使用双能 X 射线吸收法（DXA）测量四肢骨骼肌质量（ASMM），在基线和随访 2 年和 5.5 年后获得骨骼肌指数（SMI）。
在男性和女性中，均观察到 ASMM 和 SMI 在随访 2 年和 5.5 年时显著减少。重复测量方差分析（ANOVA）发现，对于 MSRA>30 和 MSRA≤30 的受试者，ASMM 存在显著的时间效应（P<0.01 和 P<0.001）。组×时间的交互作用有显著差异（P<0.001），即使考虑到基线时肌肉质量正常和低的受试者也是如此（P<0.05 和 P=0.005）。SMI 也得到了类似的结果。仅考虑基线时 SMI 正常的受试者，MSRA 问卷≤30 的受试者，其超过低肌肉质量阈值的风险增加了 5.7（95%CI 1.73-19.03）。
在社区居住的老年男性和女性人群中，MSRA 评分 30 可预测 ASMM 和 SMI 下降更快，超过 EWGSOP 低肌肉质量阈值的风险更高。
