Huang Min, Lu Jin-Jian, Ding Jian
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.
Nat Prod Bioprospect. 2021 Feb;11(1):5-13. doi: 10.1007/s13659-020-00293-7. Epub 2021 Jan 3.
Natural products, with remarkable chemical diversity, have been extensively investigated for their anticancer potential for more than a half-century. The collective efforts of the community have achieved the tremendous advancements, bringing natural products to clinical use and discovering new therapeutic opportunities, yet the challenges remain ahead. With remarkable changes in the landscape of cancer therapy and growing role of cutting-edge technologies, we may have come to a crossroads to revisit the strategies to understand nature products and to explore their therapeutic utility. This review summarizes the key advancements in nature product-centered cancer research and calls for the implementation of systematic approaches, new pharmacological models, and exploration of emerging directions to revitalize natural products search in cancer therapy.
天然产物具有显著的化学多样性，半个多世纪以来，人们对其抗癌潜力进行了广泛研究。科学界的共同努力取得了巨大进展，使天然产物进入临床应用并发现了新的治疗机会，但挑战依然存在。随着癌症治疗格局的显著变化以及前沿技术的作用不断增强，我们可能已走到一个十字路口，需要重新审视理解天然产物并探索其治疗效用的策略。本综述总结了以天然产物为中心的癌症研究的关键进展，并呼吁实施系统方法、新的药理模型以及探索新方向，以重振癌症治疗中天然产物的研究。
