Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA 44195.
Crit Rev Oncog. 2020;25(2):141-149. doi: 10.1615/CritRevOncog.2020035039.
Phytochemicals are derived from natural sources and identified to be the potential inhibitors of colorectal cancer (CRC) progression. Phytochemicals are also recognized as inhibitors of hallmarks of cancer such as invasion, migration, proliferation, angiogenesis, tumor escape immune surveillance, metastasis, etc. Phytochemicals are safe and effective drugs that are known to be associated with suppressing CRC growth and metastasis. All these accumulated evidences of phytochemicals address crucial mechanisms of CRC growth and metastasis and represent worthy consideration towards developing effective therapies. This review is focused on the functions of the most promising phytochemicals and their derivatives as potential key players that effectively target CRC progression.
植物化学物质来源于天然物质，被鉴定为结直肠癌（CRC）进展的潜在抑制剂。植物化学物质也被认为是癌症标志的抑制剂，如侵袭、迁移、增殖、血管生成、肿瘤逃避免疫监视、转移等。植物化学物质是安全有效的药物，已知与抑制 CRC 生长和转移有关。所有这些关于植物化学物质的累积证据都涉及 CRC 生长和转移的关键机制，代表了开发有效疗法的值得考虑的方向。本综述重点介绍了最有前途的植物化学物质及其衍生物的功能，作为有效靶向 CRC 进展的潜在关键因子。
