Walter Brendel Center of Experimental Medicine, BMC, Klinikum der Universität, LMU Munich, Germany; The Centenary Institute, Camperdown, New South Wales, Australia.
The Scripps Research Institute, La Jolla, California, USA.
Trends Immunol. 2018 Aug;39(8):656-669. doi: 10.1016/j.it.2018.05.003. Epub 2018 Jun 26.
The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions.
哺乳动物无育性 20 样激酶（MST）是进化古老的经典 Hippo 通路的核心组成部分，调节细胞增殖和存活。然而，令人惊讶的是，人类患者中 MST1 的缺乏会导致严重联合免疫缺陷综合征，并伴有自身免疫性疾病的特征。与此一致的是，Mst1 缺陷小鼠表现出淋巴细胞和嗜中性粒细胞功能严重缺陷，以及细胞内囊泡运输紊乱。这些发现促使人们对 MST1 在白细胞中的非典型功能进行研究。在这里，我们总结了这一主题的最新发现，并讨论了 MST1 作为各种白细胞功能的关键调节剂。
