Mohammad Sameer, Aziz Rafia, Al Mahri Saeed, Malik Shuja Shafi, Haji Esraa, Khan Altaf Husain, Khatlani Tanvir Saleem, Bouchama Abderrezak
Experimental Medicine Department, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences-MNGHA, Riyadh, 11426, Saudi Arabia.
Government Medical College Baramulla, Baramulla, Kashmir, India.
Immun Ageing. 2021 Jan 4;18(1):1. doi: 10.1186/s12979-020-00212-x.
The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symptoms but the rest of the infected cases show severe symptoms resulting in significant mortality. Age has emerged as a major factor to predict the severity of the disease and mortality rates are significantly higher in elderly patients. Besides, patients with underlying conditions like Type 2 diabetes, cardiovascular diseases, hypertension, and cancer have an increased risk of severe disease and death due to COVID-19 infection. Obesity has emerged as a novel risk factor for hospitalization and death due to COVID-19. Several independent studies have observed that people with obesity are at a greater risk of severe disease and death due to COVID-19. Here we review the published data related to obesity and overweight to assess the possible risk and outcome in Covid-19 patients based on their body weight. Besides, we explore how the obese host provides a unique microenvironment for disease pathogenesis, resulting in increased severity of the disease and poor outcome.
截至2020年10月，新型冠状病毒（COVID-19）大流行已感染数百万人，导致100多万人死亡。超过90%的COVID-19感染者症状轻微或无症状，但其余感染者则出现严重症状，导致显著的死亡率。年龄已成为预测疾病严重程度的主要因素，老年患者的死亡率明显更高。此外，患有2型糖尿病、心血管疾病、高血压和癌症等基础疾病的患者因感染COVID-19而患重病和死亡的风险增加。肥胖已成为因COVID-19住院和死亡的一个新的风险因素。多项独立研究观察到，肥胖者因COVID-19患重病和死亡的风险更大。在此，我们回顾已发表的与肥胖和超重相关的数据，以评估COVID-19患者根据其体重可能面临的风险和预后。此外，我们探讨肥胖宿主如何为疾病发病机制提供独特的微环境，导致疾病严重程度增加和预后不良。
