Department of Veterinary Clinical Sciences (Musser, Johannes) and Department of Veterinary Pathology (Viall, Phillips, Hostetter), Iowa State University College of Veterinary Medicine, 1800 Christensen Drive, Ames, Iowa 50011-1134, USA.
Can J Vet Res. 2021 Jan;85(1):68-71.
In many human cancers, the expression of the prostaglandin receptor EP4 (EP4R) is associated with the development of malignancy and a poor prognosis. The expression of EP4R has not yet been evaluated in canine tumors. The objective of this study was to characterize the messenger RNA (mRNA) expression of EP4R in canine osteosarcoma (OSA). Gene expression of EP4R was evaluated using RNA hybridization (RNAscope). In all canine OSA samples evaluated, strong universal positive expression of EP4R was identified. Gene expression was significantly higher in OSA tissue samples than in normal nasal turbinate bone, possibly implicating EP4R in the pathogenesis of canine OSA.
在许多人类癌症中，前列腺素受体 EP4（EP4R）的表达与恶性肿瘤的发展和预后不良有关。在犬肿瘤中尚未评估 EP4R 的表达。本研究的目的是描述犬骨肉瘤（OSA）中 EP4R 的信使 RNA（mRNA）表达特征。使用 RNA 杂交（RNAscope）评估 EP4R 的基因表达。在所评估的所有犬 OSA 样本中，均鉴定出 EP4R 的强烈普遍阳性表达。与正常鼻甲骨相比，OSA 组织样本中的基因表达明显更高，这可能提示 EP4R 参与了犬 OSA 的发病机制。
