Kimura Hideo
Department of Molecular Pharmacology, National Institute of Neuroscience , Kodaira, Tokyo, Japan .
Antioxid Redox Signal. 2015 Feb 10;22(5):347-9. doi: 10.1089/ars.2014.6082. Epub 2014 Oct 9.
It has been almost two decades since the first demonstration of hydrogen sulfide (H2S) as a physiological mediator of cognitive function and vascular tone. H2S is physiologically important because it protects various organs from ischemia-reperfusion injury besides regulating inflammation, oxygen sensing, cell growth, and senescence. The production, metabolism, and regulation of H2S have been studied extensively. H2S modulates target proteins through sulfhydration (or sulfuration) or by the reduction of cysteine disulfide bonds. A large number of novel H2S-donating compounds are being developed owing to the therapeutic potential of H2S. Recently, polysulfides, rather than H2S, have been identified as molecules that sulfhydrate (or sulfurate) their target proteins.
自首次证明硫化氢（H₂S）是认知功能和血管张力的生理介质以来，已经过去了近二十年。H₂S在生理上很重要，因为它除了调节炎症、氧感应、细胞生长和衰老外，还能保护各种器官免受缺血再灌注损伤。H₂S的产生、代谢和调节已经得到了广泛研究。H₂S通过硫氢化（或硫化）或通过还原半胱氨酸二硫键来调节靶蛋白。由于H₂S的治疗潜力，大量新型H₂S供体化合物正在被开发。最近，多硫化物而非H₂S已被确定为能对其靶蛋白进行硫氢化（或硫酸化）的分子。
