Department of Urology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Int J Biol Sci. 2021 Jan 1;17(1):379-389. doi: 10.7150/ijbs.54292. eCollection 2021.
circular RNA ciRS-7 (ciRS-7) is a type of endogenous circular RNA (circRNA) with a closed circular structure. Since Hansen first demonstrated that ciRS-7 could serve as a microRNA sponge in 2013, researchers have paid increased attention to this circRNA. ciRS-7 plays a crucial role in regulating RNA transcription, downstream gene expression, and protein production. Moreover, ciRS-7 acts as an oncogene and promotes tumor progression through competitively inhibiting miR-7 in various types of cancers. ciRS-7 has been identified to be closely associated with breast cancer, nasopharyngeal carcinoma, lung cancer, hepatocellular carcinoma, cervical cancer, osteosarcoma, melanoma, colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, pancreatic cancer, laryngeal squamous cell carcinoma, and cholangiocarcinoma. In this review, we summarize the biological characteristics, molecular mechanisms, and future challenges of ciRS-7 in multiple tumors.
环状 RNA ciRS-7（ciRS-7）是一种具有封闭环状结构的内源性环状 RNA（circRNA）。自 2013 年 Hansen 首次证明 ciRS-7 可以作为 microRNA 海绵以来，研究人员越来越关注这种 circRNA。ciRS-7 在调节 RNA 转录、下游基因表达和蛋白质产生方面发挥着关键作用。此外，ciRS-7 作为一种癌基因，通过在各种类型的癌症中竞争性抑制 miR-7 来促进肿瘤进展。ciRS-7 已被确定与乳腺癌、鼻咽癌、肺癌、肝癌、宫颈癌、骨肉瘤、黑色素瘤、结直肠癌、食管鳞状细胞癌、胃癌、胰腺癌、喉鳞状细胞癌和胆管癌密切相关。在这篇综述中，我们总结了 ciRS-7 在多种肿瘤中的生物学特性、分子机制和未来挑战。
