Fang Xiangdong, Hu Jing, Chen Yanxia, Shen Wen, Ke Ben
Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
The Third Hospital of Nanchang, Nanchang, China.
Front Physiol. 2020 Dec 16;11:533344. doi: 10.3389/fphys.2020.533344. eCollection 2020.
Dickkopf-related protein 3 (DKK3) is a secreted glycoprotein that has been implicated in the pathogenesis of a variety of diseases. Recent evidence suggests that urinary DKK3 may serve as a potential biomarker for monitoring kidney disease progression and assessing the effects of interventions. We review the biological role of DKK3 as an agonist in chronic kidney disease (CKD) and autosomal dominant polycystic kidney disease (ADPKD) and as an antagonist in idiopathic membranous nephropathy (IMN). In addition, we present the clinical applications of DKK3 in acute kidney disease and tubulointerstitial fibrosis, suggesting that urine DKK3 may be a potential biomarker for acute kidney disease and CKD. Further research into the mechanism of DKK3 and its use as a diagnostic tool, alone or in combination with other biomarkers, could prove clinically useful for better understanding the pathology of kidney diseases and improving early detection and treatment.
Dickkopf相关蛋白3（DKK3）是一种分泌型糖蛋白，与多种疾病的发病机制有关。最近的证据表明，尿DKK3可能作为监测肾脏疾病进展和评估干预效果的潜在生物标志物。我们综述了DKK3在慢性肾脏病（CKD）和常染色体显性多囊肾病（ADPKD）中作为激动剂以及在特发性膜性肾病（IMN）中作为拮抗剂的生物学作用。此外，我们介绍了DKK3在急性肾损伤和肾小管间质纤维化中的临床应用，提示尿DKK3可能是急性肾损伤和CKD的潜在生物标志物。对DKK3机制及其作为诊断工具（单独或与其他生物标志物联合使用）的进一步研究，可能在临床上有助于更好地理解肾脏疾病的病理，改善早期检测和治疗。
