Division of Allergy and Respiratory Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Cheongju-si, South Korea.
Division of Cardiovascular Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Cheongju-si, South Korea.
Front Public Health. 2020 Dec 16;8:575330. doi: 10.3389/fpubh.2020.575330. eCollection 2020.
It is widely known that the harmful effects of fine dust can cause various diseases. Research on the correlation between fine dust and health has been mainly focused on lung and cardiovascular diseases. By contrast, the effects of air pollution on the central nervous system (CNS) are not broadly recognized. Air pollution can cause diverse neurological disorders as the result of inflammation of the nervous system, oxidative stress, activation of microglial cells, protein condensation, and cerebral vascular-barrier disorders, but uncertainty remains concerning the biological mechanisms by which air pollution produces neurological disease. Neuronal cell damage caused by fine dust, especially in fetuses and infants, can cause permanent brain damage or lead to neurological disease in adulthood. It is necessary to study the air pollution-CNS disease connection with particular care and commitment. Moreover, the epidemiological and experimental study of the association between exposure to air pollution and CNS damage is critical to public health and quality of life. Here, we summarize the correlations between fine dust exposure and neurological disorders reported so far and make suggestions on the direction future research should take.
众所周知，细颗粒物的危害会导致各种疾病。关于细颗粒物与健康之间相关性的研究主要集中在肺部和心血管疾病上。相比之下，空气污染对中枢神经系统（CNS）的影响并没有被广泛认识。空气污染会导致神经系统炎症、氧化应激、小胶质细胞激活、蛋白质凝聚和脑血管障碍等多种神经紊乱，但空气污染如何导致神经疾病的生物学机制仍存在不确定性。细尘对神经元细胞的损害，特别是对胎儿和婴儿，会导致永久性脑损伤或导致成年后患神经疾病。因此，需要特别关注和承诺研究空气污染与中枢神经系统疾病之间的关系。此外，暴露于空气污染和中枢神经系统损伤之间的关联的流行病学和实验研究对公共卫生和生活质量至关重要。在这里，我们总结了迄今为止报道的细颗粒物暴露与神经紊乱之间的相关性，并就未来研究的方向提出了建议。
