罗马尼亚东部人群中戊型肝炎病毒的共同欧洲起源。
Common European Origin of Hepatitis E Virus in Human Population From Eastern Romania.
机构信息
Department of Public Health, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Iasi, Iaşi, Romania.
Center for the Study of Transborder and Emergent Diseases and Zoonoses Department, Danube Delta National Institute for Research and Development, Tulcea, Romania.
出版信息
Front Public Health. 2020 Dec 17;8:578163. doi: 10.3389/fpubh.2020.578163. eCollection 2020.
The purpose of this research was to improve the epidemiological data on HEV infection in the human population in Romania. The analysis targeted hospitalized subjects with acute hepatitis ( = 94) of unknown etiology from the Infectious Diseases Regional Hospital in Iasi. Moreover, patients without liver disease ( = 40) from a different county hospital located in Eastern Romania were included. The presence of HEV infection and first characterization of human HEV strains was determined using serological and molecular assays. The apparent HEV seroprevalence varied between 29.16% (95% CI, 16.31-42.03) and 32.5% (95% CI, 17.98-47.02) according to patient grouping. Molecular analysis enhanced the detection of two HEV isolates, that clustered in subtype HEV-3c, the most commonly identified subtype in Europe. Identification of acute hepatitis E cases, together with the first detection and molecular characterization of human HEV in Romania represent the originality attributes of the present study.
本研究旨在提高罗马尼亚人群中东戊型肝炎病毒（HEV）感染的流行病学数据。分析对象为来自雅西传染病地区医院的 94 例不明病因急性肝炎住院患者，以及来自罗马尼亚东部另一所不同县医院的 40 例无肝病患者。采用血清学和分子检测方法确定 HEV 感染的存在和人类 HEV 株的首次特征。根据患者分组，HEV 血清流行率分别为 29.16%（95%CI，16.31-42.03）和 32.5%（95%CI，17.98-47.02）。分子分析提高了两种 HEV 分离株的检出率，这些分离株聚类为 HEV-3c 亚型，这是欧洲最常见的亚型。急性戊型肝炎病例的鉴定，以及罗马尼亚首例人类 HEV 的检测和分子特征分析，是本研究的原创属性。
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