“同一健康”背景下克罗地亚的戊型肝炎病毒

Hepatitis E Virus in Croatia in the "One-Health" Context.

作者信息

Mrzljak Anna, Jemersic Lorena, Savic Vladimir, Balen Ivan, Ilic Maja, Jurekovic Zeljka, Pavicic-Saric Jadranka, Mikulic Danko, Vilibic-Cavlek Tatjana

机构信息

Department of Gastroenterology and Hepatology, University Hospital Center Zagreb, 10000 Zagreb, Croatia.

School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.

出版信息

Pathogens. 2021 Jun 4;10(6):699. doi: 10.3390/pathogens10060699.

DOI:10.3390/pathogens10060699

PMID:34199798

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8227679/

Abstract

Hepatitis E virus (HEV) is the most common cause of viral hepatitis globally. The first human case of autochthonous HEV infection in Croatia was reported in 2012, with the undefined zoonotic transmission of HEV genotype 3. This narrative review comprehensively addresses the current knowledge on the HEV epidemiology in humans and animals in Croatia. Published studies showed the presence of HEV antibodies in different population groups, such as chronic patients, healthcare professionals, voluntary blood donors and professionally exposed and pregnant women. The highest seroprevalence in humans was found in patients on hemodialysis in a study conducted in 2018 (27.9%). Apart from humans, different studies have confirmed the infection in pigs, wild boars and a mouse, indicating the interspecies transmission of HEV due to direct or indirect contact or as a foodborne infection. Continued periodical surveys in humans and animals are needed to identify the possible changes in the epidemiology of HEV infections.

摘要

戊型肝炎病毒（HEV）是全球病毒性肝炎最常见的病因。2012年，克罗地亚报告了首例本地戊型肝炎病毒感染的人类病例，戊型肝炎病毒3型的人畜共患病传播途径尚不明确。这篇叙述性综述全面阐述了克罗地亚关于人类和动物戊型肝炎病毒流行病学的现有知识。已发表的研究表明，不同人群中存在戊型肝炎病毒抗体，如慢性病患者、医护人员、自愿献血者以及职业暴露人群和孕妇。在2018年开展的一项研究中，血液透析患者的人类血清阳性率最高（27.9%）。除人类外，不同研究已证实猪、野猪和小鼠感染该病毒，这表明戊型肝炎病毒可通过直接或间接接触或经食物传播实现跨物种传播。需要持续对人类和动物进行定期调查，以确定戊型肝炎病毒感染流行病学可能出现的变化。