Nakazaki Masahito, Oka Shinichi, Sasaki Masanori, Kataoka-Sasaki Yuko, Nagahama Hiroshi, Hashi Kazuo, Kocsis Jeffery D, Honmou Osamu
Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan.
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA.
Heliyon. 2020 Dec 25;6(12):e05833. doi: 10.1016/j.heliyon.2020.e05833. eCollection 2020 Dec.
Intravenous infusion of mesenchymal stem cells (MSCs) has been reported to provide therapeutic efficacy via microvascular remodeling in a spontaneously hypertensive rat. In this study, we demonstrate that intravenous infusion of MSCs increased the survival rate in a spontaneously hypertensive (stroke prone) rat model in which organs including kidney, brain, heart and liver are damaged during aging due to spontaneous hypertension. Gene expression analysis indicated that infused MSCs activates transforming growth factor-β1-smad3/forkhead box O1 signaling pathway. Renal dysfunction was recovered after MSC infusion. Collectively, intravenous infusion of MSC may extend lifespan in this model system.
据报道，在自发性高血压大鼠中，静脉输注间充质干细胞（MSCs）可通过微血管重塑发挥治疗作用。在本研究中，我们证明，在自发性高血压（易中风）大鼠模型中静脉输注MSCs可提高存活率，在该模型中，由于自发性高血压，包括肾脏、大脑、心脏和肝脏在内的器官在衰老过程中会受到损害。基因表达分析表明，输注的MSCs激活了转化生长因子-β1-smad3/叉头框O1信号通路。MSCs输注后肾功能得到恢复。总体而言，在该模型系统中静脉输注MSCs可能会延长寿命。
