From the Department of Pathology, Harris County Institute of Forensic Sciences.
Pathology and Genomic Medicine Department, Houston Methodist Hospital, Houston, TX.
Am J Forensic Med Pathol. 2021 Sep 1;42(3):263-266. doi: 10.1097/PAF.0000000000000642.
Acute hemorrhagic leukoencephalitis (AHL) is an acute, hemorrhagic demyelinating disease thought to be caused by an immune-mediated process. Acute hemorrhagic leukoencephalitis is both diagnostically challenging and fatal in the majority of cases. We present two cases of AHL unexpectedly diagnosed at autopsy. These cases demonstrate the often nonspecific and challenging nature of AHL clinical presentation, review neuropathological mimics, and emphasize the importance of considering this diagnosis in the forensic setting.
急性出血性白质脑炎（AHL）是一种急性出血性脱髓鞘疾病，被认为是由免疫介导的过程引起的。在大多数情况下，急性出血性白质脑炎的诊断具有挑战性且致命。我们介绍了两例在尸检时意外诊断出的 AHL 病例。这些病例展示了 AHL 临床表现的常见非特异性和挑战性，回顾了神经病理学模拟，并强调了在法医鉴定中考虑这种诊断的重要性。
