Division of Rheumatology and Clinical Immunology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Curr Opin Rheumatol. 2021 Mar 1;33(2):163-172. doi: 10.1097/BOR.0000000000000778.
TCRαβ+CD4-CD8- double-negative T (DNT) cells, a principal subset of mature T lymphocytes, have been closely linked with autoimmune/inflammatory conditions. However, controversy persists regarding their ontogeny and function. Here, we present an overview on DNT cells in different autoimmune diseases to advance a deeper understanding of the contribution of this population to disease pathogenesis.
DNT cells have been characterized in various chronic inflammatory diseases and they have been proposed to display pathogenic or regulatory function. The tissue location of DNT cells and the effector cytokines they produce bespeak to their active involvement in chronic inflammatory diseases.
By producing various cytokines, expanded DNT cells in inflamed tissues contribute to the pathogenesis of a variety of autoimmune inflammatory diseases. However, it is unclear whether this population represents a stable lineage consisting of different subsets similar to CD4+ T helper cell subset. Better understanding of the possible heterogeneity and plasticity of DNT cells is needed to reveal interventional therapeutic opportunities.
TCRαβ+CD4-CD8-双阴性 T（DNT）细胞是成熟 T 淋巴细胞的主要亚群之一，与自身免疫/炎症性疾病密切相关。然而，关于其发生和功能仍存在争议。在这里，我们综述了不同自身免疫性疾病中的 DNT 细胞，以深入了解该群体对疾病发病机制的贡献。
在各种慢性炎症性疾病中已经对 DNT 细胞进行了描述，并提出它们具有致病性或调节功能。DNT 细胞在组织中的位置及其产生的效应细胞因子表明它们积极参与慢性炎症性疾病。
在炎症组织中扩增的产生各种细胞因子的 DNT 细胞有助于多种自身免疫性炎症性疾病的发病机制。然而，尚不清楚该群体是否代表类似于 CD4+T 辅助细胞亚群的不同亚群组成的稳定谱系。需要更好地了解 DNT 细胞的可能异质性和可塑性，以揭示干预治疗的机会。
