Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai.
Psychiatry Department, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Psychiatr Genet. 2021 Feb 1;31(1):21-28. doi: 10.1097/YPG.0000000000000275.
Previous studies and meta-analysis indicated that rs1344706 was associated with schizophrenia in European population, whereas the conclusions in other populations were disputed. To further explore whether the allele A of rs1344706 would increase the risk of schizophrenia in different populations and update the original meta-analysis, we conducted a systematic review and meta-analysis worldwide.
A literature search was performed in PubMed, Embase, Cochrane Library, PsycINFO and Web of Science (up to 10 July 2019) according to the inclusion criteria.
A total of 27 articles were included. Our meta-analysis showed an association between rs1344706 and schizophrenia in total populations [P = 0.000; odds ratio (OR) = 1.105; 95% confidence interval (CI), 1.048-1.165], Europe population (P = 0.025; OR = 1.108; 95% CI, 1.013-1.222) and Asian population(P = 0.005; OR = 1.094; 95% CI, 1.027-1.164).
Our findings suggested that the risk of single nucleotide polymorphism rs1344706 A-allele may increase the risk of schizophrenia worldwide. Also, this ethnicity-dependent effects of ZNF804A variant on schizophrenia may be related to the opposite allele direction. But to elucidate the underlying biological mechanism, further studies with large participant populations are needed.
先前的研究和荟萃分析表明，rs1344706 与欧洲人群中的精神分裂症有关，而其他人群的结论存在争议。为了进一步探讨 rs1344706 的等位基因 A 是否会增加不同人群患精神分裂症的风险，并更新原始的荟萃分析，我们在全球范围内进行了系统的综述和荟萃分析。
根据纳入标准，在 PubMed、Embase、Cochrane 图书馆、PsycINFO 和 Web of Science 中进行了文献检索（截至 2019 年 7 月 10 日）。
共纳入 27 篇文章。我们的荟萃分析显示，rs1344706 与总体人群中的精神分裂症之间存在关联[P = 0.000；优势比（OR）=1.105；95%置信区间（CI），1.048-1.165]、欧洲人群（P = 0.025；OR = 1.108；95% CI，1.013-1.222）和亚洲人群（P = 0.005；OR = 1.094；95% CI，1.027-1.164）。
我们的研究结果表明，单核苷酸多态性 rs1344706 A 等位基因的风险可能会增加全球范围内精神分裂症的风险。此外，ZNF804A 变异对精神分裂症的这种种族依赖效应可能与相反的等位基因方向有关。但是，为了阐明潜在的生物学机制，还需要进行具有更大参与者人群的进一步研究。
