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ZNF804A基因rs1344706多态性与健康个体脑功能的关联：一项系统综述和基于体素的荟萃分析

Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis.

作者信息

Yang Liqiong, Xu Fan, He Yi, Li Yanzhang, Chen Zi, Wang Shuai

机构信息

Department of Pharmacy, Chengdu Medical College, Chengdu, 610500, People's Republic of China.

Department of Public Health, Chengdu Medical College, Chengdu, 610500, People's Republic of China.

出版信息

Neuropsychiatr Dis Treat. 2021 Sep 14;17:2925-2935. doi: 10.2147/NDT.S322114. eCollection 2021.

DOI:10.2147/NDT.S322114
PMID:34548792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8449690/
Abstract

OBJECTIVE

Zinc finger protein 804A (ZNF804A) protein participates in embryonic neural repair and development. The single nucleotide polymorphism rs1344706 in ZNF804A gene is closely related to functional abnormalities of the human brain. However, these results are inconsistent. This association was verified by meta-analysis in this study.

METHODS

Fifteen studies on functional magnetic resonance imaging involving 1710 healthy individuals were included in the systematic review and meta-analysis used by Anisotropic Effect-Size Signed Differential Mapping software.

RESULTS

Functional connectivity of the right dorsolateral prefrontal cortex (rDLPFC)-left hippocampus in the rs1344706 risk allele carrier was significantly increased ( = 2.066, < 0.001), while those in the rDLPFC-left middle frontal gyrus ( = -1.420, < 0.001) and rDLPFC-right middle frontal gyrus ( = -1.298, < 0.001) were significantly decreased. Neural activity of the left anterior cingulate gyrus in the rs1344706 risk allele carrier was significantly decreased ( = -2.525, < 0.001). Sensitivity analysis was almost stable, and no publication bias was found.

CONCLUSION

The changes in brain function have a clear correlation with ZNF804A gene in healthy individuals, which indicate the contribution of genetic variants on brain dysfunction.

REGISTRATION NUMBER

This meta-analysis is registered in PROSPERO (No. CRD42016051331).

摘要

目的

锌指蛋白804A（ZNF804A）蛋白参与胚胎神经修复与发育。ZNF804A基因中的单核苷酸多态性rs1344706与人类大脑功能异常密切相关。然而，这些结果并不一致。本研究通过荟萃分析对这种关联进行了验证。

方法

纳入15项关于功能磁共振成像的研究，涉及1710名健康个体，采用各向异性效应大小符号差分映射软件进行系统评价和荟萃分析。

结果

rs1344706风险等位基因携带者右侧背外侧前额叶皮质（rDLPFC）-左侧海马的功能连接显著增加（=2.066，<0.001），而rDLPFC-左侧额中回（=-1.420，<0.001）和rDLPFC-右侧额中回（=-1.298，<0.001）的功能连接显著降低。rs1344706风险等位基因携带者左侧前扣带回的神经活动显著降低（=-2.525，<0.001）。敏感性分析基本稳定，未发现发表偏倚。

结论

健康个体的脑功能变化与ZNF804A基因有明显相关性，这表明基因变异对脑功能障碍有影响。

注册号

本荟萃分析已在PROSPERO注册（注册号：CRD42016051331）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b1/8449690/6cf35bc7f5bc/NDT-17-2925-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b1/8449690/3f69a441ebf4/NDT-17-2925-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b1/8449690/f23106095023/NDT-17-2925-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b1/8449690/8bdabab8ee07/NDT-17-2925-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b1/8449690/b8a048d63b6e/NDT-17-2925-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b1/8449690/6cf35bc7f5bc/NDT-17-2925-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b1/8449690/3f69a441ebf4/NDT-17-2925-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b1/8449690/f23106095023/NDT-17-2925-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b1/8449690/8bdabab8ee07/NDT-17-2925-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b1/8449690/b8a048d63b6e/NDT-17-2925-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b1/8449690/6cf35bc7f5bc/NDT-17-2925-g0005.jpg

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