Do Phuong Anh, Lee Chang Hoon
Phamaceutical Biochemistry, College of Pharmacy, BK21 FOUR Team, and Integrated Research Institute for Drug Development, Dongguk University, Goyang 100-715, Korea.
Cancers (Basel). 2020 Dec 31;13(1):101. doi: 10.3390/cancers13010101.
Cyclin-dependent kinase 5 (CDK5), which belongs to the protein kinase family, regulates neuronal function but is also associated with cancer development and has been proposed as a target for cancer treatment. Indeed, CDK5 has roles in cell proliferation, apoptosis, angiogenesis, inflammation, and immune response. Aberrant CDK5 activation triggers tumour progression in numerous types of cancer. In this review, we summarise the role of CDK5 in cancer and neurons and CDK5 inhibitors. We expect that our review helps researchers to develop CDK5 inhibitors as treatments for refractory cancer.
细胞周期蛋白依赖性激酶5（CDK5）属于蛋白激酶家族，它调节神经元功能，但也与癌症发展相关，并且已被提议作为癌症治疗的靶点。事实上，CDK5在细胞增殖、凋亡、血管生成、炎症和免疫反应中发挥作用。CDK5的异常激活会引发多种类型癌症的肿瘤进展。在本综述中，我们总结了CDK5在癌症和神经元中的作用以及CDK5抑制剂。我们期望我们的综述能帮助研究人员开发CDK5抑制剂作为难治性癌症的治疗方法。
