Waszczykowski Michał, Fabiś-Strobin Anna, Bednarski Igor, Lesiak Aleksandra, Narbutt Joanna, Fabiś Jarosław
Department of Arthroscopy, Minimally Invasive Surgery and Sports Traumatology, Medical University of Lodz, Kosciuszki 4, 90-419 Lodz, Poland.
Clinic of Orthopaedic and Traumatology, Polish Mother's Memorial Hospital Research Institute, Rzgowska 281/289, 93-338 Lodz, Poland.
Diagnostics (Basel). 2020 Dec 31;11(1):52. doi: 10.3390/diagnostics11010052.
The aim of this study was to find characteristic biomarkers in the serum of patients with osteoarthritis (OA) and psoriatic arthritis (PsA) responsible for inflammation and destruction of joint cartilage, which could differentiate these two diseases. The study included 67 people: 22 patients with knee OA, 22 patients with PsA, and 23 individuals who were the control group of healthy individuals (HC). The concentration of IL-18, IL-20, IL-6, MMP-1, MMP-3, COMP, PG-AG, and YKL-40 in serum were determined. Among the OA and PsA patients group, the radiological assessment and clinical assessment were also performed. The concentration of 7 out of 8 of examined biomarkers (except MMP-1) was statistically significantly higher in the serum of patients with OA and PsA than in the control group. Compering OA and PsA groups only, the serum PG-AG level in OA patients was statistically significantly higher than in PsA patients ( < 0.001). The results of univariate and multivariate logistic regression analysis comparing OA and PsA biomarker serum levels identified PG-AG and COMP as markers that are significantly different between patients with OA and PsA (odds ratio 0.995 and 1.003, respectively). The ROC curve constructed using the model with age showed PG-AG and COMP had an AUC of 0.907. The results of this study show that COMP and PG-AG may be sensitive markers differentiating patients with osteoarthiritis from psoriatic arthritis.
本研究的目的是在骨关节炎（OA）和银屑病关节炎（PsA）患者的血清中寻找导致关节软骨炎症和破坏的特征性生物标志物，这些生物标志物可以区分这两种疾病。该研究纳入了67人：22例膝关节OA患者、22例PsA患者以及23名作为健康对照（HC）的个体。测定了血清中IL-18、IL-20、IL-6、MMP-1、MMP-3、COMP、PG-AG和YKL-40的浓度。在OA和PsA患者组中，还进行了放射学评估和临床评估。在OA和PsA患者血清中，8种检测生物标志物中的7种（除MMP-1外）的浓度在统计学上显著高于对照组。仅比较OA和PsA组，OA患者血清中的PG-AG水平在统计学上显著高于PsA患者（<0.001）。比较OA和PsA生物标志物血清水平的单因素和多因素逻辑回归分析结果确定，PG-AG和COMP是OA和PsA患者之间存在显著差异的标志物（优势比分别为0.995和1.003）。使用包含年龄的模型构建的ROC曲线显示，PG-AG和COMP的AUC为0.907。本研究结果表明，COMP和PG-AG可能是区分骨关节炎患者和银屑病关节炎患者的敏感标志物。
