Nucera Eleonora, Inchingolo Riccardo, Nicotra Rosario, Ferraironi Manuela, Ricci Anna Giulia, Parrinello Giuseppe, La Sorda Marilena, Sanguinetti Maurizio, Gasbarrini Antonio, Rizzi Angela
UOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
UOC Pneumologia, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy.
Diagnostics (Basel). 2020 Dec 30;11(1):44. doi: 10.3390/diagnostics11010044.
The basophil activation test (BAT) is used to improve the accuracy of food allergy diagnosis. To date, the influence of antiallergic drugs on BAT reactivity is poorly investigated. The aim of the study was to investigate if BAT results were influenced by antihistamine intake for 3 months in a cohort of patients with IgE-mediated food allergy to milk or egg.
A retrospective, single-center, observational study was performed. We enrolled subjects with history of hypersensitivity reaction after specific food ingestion, positive skin prick tests and specific IgEs, concomitant allergic rhinitis, and, contraindication to the double-blind, placebo-controlled food challenge due to personal history of systemic reactions related to the ingestion of culprit food. Validated allergens (α-lactoalbumin, β-lactoglobulin, casein, egg white, and yolk) for BAT were used.
Thirty-nine patients with well-documented food symptoms and positive allergological workup were included in the study. BAT was positive in 29 patients. The mean percentages of CD63+ expression to specific culprit allergen did not change after the administration of drugs.
This was the first study assessing the effects of oral antihistamines on basophil reactivity in cow's milk and egg food allergy. Antihistamines do not interfere with BAT results.
嗜碱性粒细胞活化试验（BAT）用于提高食物过敏诊断的准确性。迄今为止，抗组胺药对BAT反应性的影响研究较少。本研究的目的是调查在一组对牛奶或鸡蛋有IgE介导的食物过敏的患者中，服用抗组胺药3个月是否会影响BAT结果。
进行了一项回顾性、单中心观察性研究。我们纳入了有特定食物摄入后过敏反应史、皮肤点刺试验和特异性IgE阳性、伴有过敏性鼻炎，以及因摄入致病食物有全身反应个人史而禁忌进行双盲、安慰剂对照食物激发试验的受试者。使用了经验证的用于BAT的变应原（α-乳白蛋白、β-乳球蛋白、酪蛋白、蛋清和蛋黄）。
39例有充分记录的食物症状且变应原检查阳性的患者纳入研究。29例患者的BAT呈阳性。服用药物后，针对特定致病变应原的CD63 +表达的平均百分比没有变化。
这是第一项评估口服抗组胺药对牛奶和鸡蛋食物过敏中嗜碱性粒细胞反应性影响的研究。抗组胺药不干扰BAT结果。
