Saré Rachel Michelle, Lemons Abigail, Song Alex, Smith Carolyn Beebe
Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Section on Neuroadaptation and Protein Metabolism, Bethesda, MD 20814, USA.
Brain Sci. 2020 Dec 30;11(1):31. doi: 10.3390/brainsci11010031.
Sleep abnormalities are common in patients with neurodevelopmental disorders, and it is thought that deficits in sleep may contribute to the unfolding of symptoms in these disorders. Appreciating sleep abnormalities in neurodevelopmental disorders could be important for designing a treatment for these disorders. We studied sleep duration in three mouse models by means of home-cage monitoring: (tuberous sclerosis complex), oxytocin receptor () knockout (KO) (autism spectrum disorders), and KO (Phelan-McDermid syndrome). We studied both male and female mice, and data were analyzed to examine effects of both genotype and sex. In general, we found that female mice slept less than males regardless of genotype or phase. We did not find any differences in sleep duration in either or KO mice, compared to controls. In KO mice, we found a statistically significant genotype x phase interaction ( = 0.002) with a trend that KO mice regardless of sex slept more than control mice in the active phase. Our results have implications for the management of patients with Phelan-McDermid syndrome.
睡眠异常在神经发育障碍患者中很常见，人们认为睡眠不足可能导致这些疾病症状的显现。认识到神经发育障碍中的睡眠异常对于设计这些疾病的治疗方法可能很重要。我们通过笼内监测研究了三种小鼠模型的睡眠时间：结节性硬化症复合体、催产素受体基因敲除（KO）（自闭症谱系障碍）和基因敲除（费伦 - 麦克德米德综合征）。我们研究了雄性和雌性小鼠，并对数据进行分析以检查基因型和性别的影响。总体而言，我们发现无论基因型或阶段如何，雌性小鼠的睡眠时间都比雄性少。与对照组相比，我们在基因敲除或基因敲除小鼠中未发现睡眠时间有任何差异。在基因敲除小鼠中，我们发现了一个具有统计学意义的基因型×阶段相互作用（P = 0.002），趋势是无论性别，基因敲除小鼠在活跃期的睡眠时间都比对照小鼠长。我们的结果对费伦 - 麦克德米德综合征患者的管理具有启示意义。
