Aheget Houssam, Mazini Loubna, Martin Francisco, Belqat Boutaïna, Marchal Juan Antonio, Benabdellah Karim
GENYO Centre for Genomics and Oncological Research, Genomic Medicine Department, Pfizer/University of Granada/Andalusian Regional Government, Health Sciences Technology Park, Av. de la Illustration 114, 18016 Granada, Spain.
Department of Biology, Faculty of Sciences, University Abdelmalek Essaâdi, Tétouan 93000, Morocco.
Cancers (Basel). 2020 Dec 30;13(1):84. doi: 10.3390/cancers13010084.
Exosomes are lipid bilayer particles released from cells into their surrounding environment. These vesicles are mediators of near and long-distance intercellular communication and affect various aspects of cell biology. In addition to their biological function, they play an increasingly important role both in diagnosis and as therapeutic agents. In this paper, we review recent literature related to the molecular composition of exosomes, paying special attention to their role in pathogenesis, along with their application as biomarkers and as therapeutic tools. In this context, we analyze the potential use of exosomes in biomedicine, as well as the limitations that preclude their wider application.
外泌体是从细胞释放到其周围环境中的脂质双层颗粒。这些囊泡是近距离和远距离细胞间通讯的介质，并影响细胞生物学的各个方面。除了其生物学功能外，它们在诊断和作为治疗剂方面都发挥着越来越重要的作用。在本文中，我们综述了与外泌体分子组成相关的最新文献，特别关注它们在发病机制中的作用，以及它们作为生物标志物和治疗工具的应用。在此背景下，我们分析了外泌体在生物医学中的潜在用途，以及阻碍其更广泛应用的局限性。
