UMR-T 1158, BioEcoAgro, University of Lille, F-59000 Lille, France.
Diana Pet Food, F-56250 Elven, France.
Molecules. 2020 Dec 30;26(1):136. doi: 10.3390/molecules26010136.
Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply. Through numerous studies, fish protein hydrolysates have proved their worth to prevent and manage obesity-related comorbidities like diabetes. In this work, a human in vitro static simulated gastrointestinal digestion model was adapted to the dog which allowed us to demonstrate the promising effects of a tilapia byproduct hydrolysate on the regulation of food intake and glucose metabolism. Promising effects on intestinal hormones secretion and dipeptidyl peptidase IV (DPP-IV) inhibitory activity were evidenced. We identify new bioactive peptides able to stimulate cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) secretions, and to inhibit the DPP-IV activity after a transport study through a Caco-2 cell monolayer.
与它们的主人一样，狗和猫越来越受到超重和肥胖相关问题的影响，人们对功能性宠物食品的兴趣也急剧增加。通过大量研究，鱼蛋白水解物已被证明可预防和控制肥胖相关的合并症，如糖尿病。在这项工作中，我们对人类体外静态模拟胃肠道消化模型进行了适应，使其适用于狗，这使我们能够证明罗非鱼副产物水解物在调节食物摄入和葡萄糖代谢方面的有希望的效果。证明了对肠道激素分泌和二肽基肽酶 IV（DPP-IV）抑制活性的有希望的影响。我们鉴定了新的生物活性肽，它们能够刺激胆囊收缩素（CCK）和胰高血糖素样肽 1（GLP-1）的分泌，并在通过 Caco-2 细胞单层进行转运研究后抑制 DPP-IV 活性。
