Department of Biochemistry, University of Health Sciences, Konya Health Application and Research Center, Konya, Turkey.
Department of Nephrology, University of Health Sciences, Konya Health Application and Research Center, Konya, Turkey.
J Coll Physicians Surg Pak. 2020 Dec;30(12):1273-1278. doi: 10.29271/jcpsp.2020.12.1273.
To investigate the correlation between depression severity and oxidative stress in patients undergoing hemodialysis (HD) using thiol disulfide homeostasis (TDH).
Descriptive, analytical study.
Konya Health Application and Research Center, Konya, Turkey from September 2019 to March 2020.
A total of 67 patients including 35 males (52.2%) and 32 females (47.8%), receiving HD treatment, were included in the study. The Hamilton depression rating scale (HAM-D) was applied to the participants. Thiol disulfide homeostasis (total thiol (TT), native thiol (NT), disulfide, disulfide/NT ratio, disulfide/TT ratio, and NT/TT ratio) parameters, albumin, and ischemia modified albumin (IMA) levels were determined. The study groups were investigated by dividing them into groups according to their gender and HAM-D score.
According to HAM-D score, there were 32 (47.8%) patients with depression symptom (DS, HAM-D score of ≥8) and 35 (52.2%) patients without DS (HAM-D score: 0-7). Modified Charlson comorbidity index (MCCI), disulfide, disulfide/NT%, and disulfide/TT% levels were statistically and significantly higher and NT/TT% was statistically and significantly lower in DS group than the values of the groups without DS (p = 0.003, p =0.043, p = 0.017, p=0.017 and p = 0.017, respectively). HAM-D score and MCCI were statistically and significantly higher in females than males (p <0.001, p = 0.001, respectively). While, 21 patients (65.6%) had DS in women; according to HAM-D score, this rate was found to be statistically higher than men (11 patients, 31.4%, p = 0.005).
Almost half of HD patients had at least moderate depression symptoms. In the group of HD patients with DS, TDH shifted in the oxidative direction. This may contribute to the future studies in enlightening depression etiology in HD patients. Key Words: Hemodialysis, Depression, Thiol disulfide homeostasis (TDH), IMA.
使用硫醇二硫化物稳态（TDH）研究接受血液透析（HD）治疗的患者的抑郁严重程度与氧化应激之间的相关性。
描述性、分析性研究。
土耳其科尼亚健康应用与研究中心，2019 年 9 月至 2020 年 3 月。
共纳入 67 例患者，其中男性 35 例（52.2%），女性 32 例（47.8%），接受 HD 治疗。对参与者应用汉密尔顿抑郁评定量表（HAM-D）。测定硫醇二硫化物稳态（总硫（TT）、天然硫（NT）、二硫化物、二硫化物/NT 比值、二硫化物/TT 比值和 NT/TT 比值）、白蛋白和缺血修饰白蛋白（IMA）水平。根据性别和 HAM-D 评分将研究对象分为不同的组。
根据 HAM-D 评分，32 例（47.8%）患者有抑郁症状（DS，HAM-D 评分≥8），35 例（52.2%）患者无 DS（HAM-D 评分：0-7）。DS 组的改良 Charlson 合并症指数（MCCI）、二硫化物、二硫化物/NT%和二硫化物/TT%水平明显高于无 DS 组（p=0.003、p=0.043、p=0.017 和 p=0.017），而 NT/TT%水平明显低于无 DS 组（p=0.017）。女性的 HAM-D 评分和 MCCI 明显高于男性（p＜0.001、p=0.001）。然而，21 例（65.6%）女性患者有 DS；根据 HAM-D 评分，这一比例明显高于男性（11 例，31.4%，p=0.005）。
近一半的血液透析患者至少有中度抑郁症状。在有 DS 的 HD 患者中，TDH 向氧化方向转移。这可能有助于未来的研究阐明 HD 患者抑郁的病因。关键词：血液透析、抑郁、硫醇二硫化物稳态（TDH）、IMA。
